Melon breeding is directed at improving the quality of the fruit needed to meet consumers' demands. e assessment of hybrid melon candidates on important characteristics (vitamin A, vitamin C, and TSS) at ve maturity stages is needed to get hybrid melon varieties with good fruit quality and determine the right harvest time. is study aimed to evaluate the genetic parameters of vitamin A, vitamin C, and TSS contents of D-612 × PK-669 and PK-361 × PK-165 crossings at ve stages of maturity. e study used a randomized complete block design (RCBD) with eight genotypes as treatment and three replications, so there were 24 experimental units.e eight melon genotypes were G 1 = D-612 × PK-669, G 2 = PK-669 × D-612, G 3 = D-612, G 4 = PK-669, G 5 = PK-361 × PK-165, G 6 = PK-165 × PK-361, G 7 = PK-361, and G 8 = PK-165. e content of vitamin A, vitamin C, and TSS was observed at ve maturity stages, namely, at 55 DAP, 60 DAP, 65 DAP, 70 DAP, and 75 DAP. e right harvest time for the eight genotypes tested was maturity stage 4 (70 DAP) because it had the highest vitamin A, vitamin C, and TSS contents compared to other maturity stages. e inheritance of vitamin A and C content was not a ected by the maternal e ect, while TSS was in uenced by the maternal e ect. e vitamin A, vitamin C, and TSS content characteristics had higher phenotypic diversity coe cients than genetic diversity coe cients, while heritability values in the broad sense for the three melon genotypic characteristics ranged from 0.613 to 0.968. Crosses of PK-165 × PK-361 can be used to assemble hybrid melon varieties that have high vitamin A, vitamin C, and TSS contents because they have positive values for heterosis and heterobeltiosis for the three characteristics.