Achieving adequate healing in large or load-bearing bone defects is highly challenging even with surgical intervention. The clinical standard of repairing bone defects using autografts or allografts has many drawbacks. A bioactive ceramic scaffold, strontium-hardystonite-gahnite or "Sr-HT-Gahnite" (a multi-component, calcium silicate-based ceramic) is developed, which when 3D-printed combines high strength with outstanding bone regeneration ability. In this study, the performance of purely synthetic, 3D-printed Sr-HT-Gahnite scaffolds is assessed in repairing large and load-bearing bone defects. The scaffolds are implanted into critical-sized segmental defects in sheep tibia for 3 and 12 months, with bone autografts used for comparison. The scaffolds induce substantial bone formation and defect bridging after 12 months, as indicated by X-ray, micro-computed tomography, and histological and biomechanical analyses. Detailed analysis of the bone-scaffold interface using focused ion beam scanning electron microscopy and multiphoton microscopy shows scaffold degradation and maturation of the newly formed bone. In silico modeling of strain energy distribution in the scaffolds reveal the importance of surgical fixation and mechanical loading on long-term bone regeneration. The clinical application of 3D-printed Sr-HT-Gahnite scaffolds as a synthetic bone substitute can potentially improve the repair of challenging bone defects and overcome the limitations of bone graft transplantation.
To achieve adequate healing in large or load-bearing bone defects is highly challenging even with surgical intervention. The clinical standard of repairing bone defects using autologous or allogeneic bone grafts has many drawbacks. We have developed a bioactive ceramic scaffold, strontium-hardystonite-gahnite or "Sr-HT-Gahnite" (a multi-component, calcium silicatebased ceramic), which when 3D printed combines high strength with outstanding bone regeneration ability. In this study, we assess the performance of purely synthetic, 3D printed Sr-HT-Gahnite scaffolds in repairing large and load-bearing bone defects. The scaffolds are implanted into critical-sized segmental defects in sheep tibia for 3 and 12 months, with autologous bone grafts used for comparison. The scaffolds induce substantial bone formation and defect bridging after 12 months, as indicated by X-ray, micro-computed tomography, histological and biomechanical analyses. Detailed analysis of the bone-scaffold interface using focused ion beam scanning electron microscopy and multiphoton microscopy show evidence of scaffold degradation and maturation of the newly formed bone. In silico modeling of strain energy distribution in the scaffolds reveal the importance of surgical fixation and mechanical loading on long-term bone regeneration. The clinical application of 3D printed Sr-HT-Gahnite scaffolds as a synthetic bone substitute can potentially improve the repair of challenging bone defects, and overcome the limitations of bone graft transplantation.
Purpose The purposes of the present research were to assess the accuracy and usability of the inertial navigation system (INS). Materials and Methods The accuracy of the device navigation subsystem was assessed using benchtop testing. The usability was assessed through simulated use with surgeons. These results were compared to recent cadaveric results for the same system. Results The navigation subsystem had an overall mean absolute error of 1.21° and a maximum absolute error across all devices of 4.79°. The device was found to be usable and to add an estimated 7 minutes to surgery time. Conclusion The INS uses a novel approach to provide the surgeon with accurate and fast acetabular cup inclination and anteversion angles during THA.
In this work, we measured the mechanical properties and tested the cell viability of a bioceramic coating, strontium–hardystonite–gahnite (Sr–HT–G, Sr–Ca2ZnSi2O7–ZnAl2O4), to evaluate potential use of this novel bioceramic for bone regeneration applications. The evaluation of Sr–HT–G coatings deposited via atmospheric plasma spray (APS) onto Ti–6Al–4V substrates have been contrasted to the properties of the well-known commercial standard coating of hydroxyapatite (HAp: Ca10(PO4)6(OH)2). The Sr–HT–G coating exhibited uniform distribution of hardness and elastic moduli across its cross-section; whereas the HAp coating presented large statistical variations of these distributions. The Sr–HT–G coating also revealed higher results of microhardness, nanohardness and elastic moduli than those shown for the HAp coating. The nanoscratch tests for the Sr–HT–G coating presented a low volume of material removal without high plastic deformation, while the HAp coating revealed ploughing behaviour with a large pileup of materials and plastic deformation along the scratch direction. Furthermore, nanoscanning wear tests indicated that Sr–HT–G had a lower wear volume than the HAp coating. The Sr–HT–G coating had slightly higher cell attachment density and spreading area compared to the HAp coating indicating that both coatings have good biocompatibility for bone marrow mesenchymal stem cells (BMSCs).
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