HHV8/EBV-associated germinotropic lymphoproliferative disorder (GLD) is a challenging diagnosis given its rarity, the particular clinical presentation, and the lack of expression of markers usually used in establishing hematopoietic lineage. We report a new case of HHV8/EBV GLD in an immunocompetent 78-year-old woman. The diagnosis was made in an incidentally discovered lymphadenopathy. Histological examination showed a nodular lymphoid proliferation centered by aggregates of atypical plasmablastic cells admixed with small lymphoid cells. Tumor cells were strongly positive with EMA, HHV8, LMP1, CD38, CD138, and kappa light chains. They were negative with common lymphoma-associated markers (CD20, CD3, CD15, CD30, CD10, and bcl2). In situ hybridization confirmed the monotypic kappa light chains and the EBV infection (EBER+). A polyclonal pattern of Ig gene rearrangement was detected by PCR analysis. In the adjacent lymph node parenchyma, some germinal centers mimicked Castleman disease. In this case, the differential diagnosis was discussed with an early stage of large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease. The clinical presentation, the immunophenotype, and the molecular results helped to make the accurate diagnosis. Through the review of the nine previously reported cases in literature, we discuss the clinical and pathologic features and the differential diagnosis of HHV8/EBV GLD.
-Introduction:Ameloblastoma is the most common aggressive benign odontogenic tumor of the jaws. This kind of tumor arises from dental embryonic remnants. Clinical case: We report a case of acanthomatous ameloblastoma of the mandible occurring in a 79-year-old male patient. Through this case, we describe clinical and radiological findings in ameloblastoma, discuss different variants of this tumor, and emphasize the histological diagnosis. Discussion: Among the various types of aggressive benign odontogenic tumors, acanthomatous ameloblastoma represents a subtype of the solid multicystic ameloblastoma with specific microscopic features. Its course is controversial. Conclusion: Although the diagnosis of acanthomatous ameloblastoma is based on histologic features, dentists and oral surgeons should consider this possibility in patients with an aggressive tumoral process.Résumé -Une variante histologique d'améloblastome : le type acnthomateux. Introduction : L'améloblastome est la plus commune des tumeurs agressives odontogènes bénignes des maxillaires. Elle provient des vestiges embryonnaires de l'organe dentaire. Observation : Nous rapportons un cas d'améloblastome acanthomateux de la mandibule chez un patient âgé de 79 ans. A travers cette observation clinique, nous décrivons les caractéristiques cliniques et radiologiques de l'améloblastome en rappelant les différents types histologiques particulièrement le type acanthomateux. Discussion : L'améloblastome acanthomateux est une variante de l'améloblastome solide multikystique qui possède des caractéristiques microscopiques spécifiques. Son évolution reste controversée. Conclusion : Même si son diagnostic est histologique, le chirurgien-dentiste doit savoir évoquer une telle hypothèse face à un processus tumoral agressif.
Oncocytic carcinomas of the salivary glands are rare. The submandibular gland is a rare location. It is usually associated with a poor prognosis and recurrence after treatment. We report a case of a 52‐year‐old man with a lymph node and brain metastasis recurrence of an oncocytic carcinoma of the submandibular gland.
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