Objectives
To highlight recent advances in the conceptualization of Attention-Deficit/Hyperactivity Disorder (ADHD) emerging from neuroimaging and endophenotypic approaches.
Methods
Selective review of the recent published literature on the phenomena of resting state functional connectivity, intra-subject variability, and diffusion tensor imaging pertaining to ADHD.
Results
Recent advances based on the novel approach of resting state functional connectivity appear to be highly promising and likely to link to studies of intra-subject variability.
Conclusions
Endophenotypic fractionation may offer a means of addressing the complex heterogeneity of ADHD on the path to testable models of pathophysiology. Such models focusing on intra-subject variability, intrinsic brain activity, and reward-related processing are progressing rapidly.
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