Fibrosis stage and week 2 and 4 hematological parameter reduction levels were independent predictors of hematological side effects, which are not related to interferon type.

Background: In December of 2019, Wuhan, a new coronaviruscaused pandemic of atypical pneumonia was reported by China. This study determined IL-6 value in disease severity assessment of COVID-19 patients without preexisting pathologies. Methods: This cross-sectional study was conducted on 100 participants. They were classified into group A included 25 patients classified as mild or moderate cases, group B included 25 patients classified as severe cases, group C included 25 patients classified as critical ill cases and all was positive PCR COVID-19 and group D (Control Group) included 25 healthy individuals. Participants were subjected to history taking, Serum IL-6 measurement using ELISA, laboratory investigations and imaging. Results: IL-6 significantly differed between the studied groups (P < 0.001). IL-6 showed significant positive correlations with age (r = 0.338, P = 0.003), SBP (r = 0.288, P = 0.012), temperature (r = 0.262, P = 0.023), respiratory rate (r = 0.729, P < 0.001), D-dimer (r = 0.704, P < 0.001), ferritin (r = 0.791, P < 0.001), CRP (r = 0.592, P < 0.001), and severity (r = 0.821, P < 0.001). Multinomial logistic regression analysis revealed that IL-6 was a significant predictor for mild to moderate covid (OR = 7.66, 95% CI = 2.212 -26.528, P = 0.001), severe covid (OR = 17.727, 95% CI = 4.545 -69.141, P < 0.001), and critically ill patients (OR = 24.345, 95% CI = 6.135-96.604, P < 0.001). Conclusion: IL-6 can significantly predict COVID-19 severity (mild to moderate, severe and critically ill) and mortality.

Ultrasound is often the first technique used for the detection and characterisation of focal liver lesions because of its availability, low cost and safety. Shockingly, the affectability and particularity of regular ultrasound is under 70 % for the recognition and characterisation of central liver injuries (FLLs). assess the job of ongoing elastography ultrasound method in portrayal of various HFLS. This is an imminent report, The patients were isolated reflectively into three gatherings: Group 1: included 148 patients who were analyzed as essential harm including hepatocellular carcinoma (HCC) and chlolangiocarcinoma. Gathering 2: included 23 patients who were analyzed as kind injuries, for example, hemangioma, sores and FNH. Gathering 3: included 29 patients who analyzed as metastatic sores, patients were exposed to full history taking, total clinical assessment, lab examinations and imaging as Abdominal ultrasonography, Triphasic CT check ; Dynamic MRI with dissemination; and US guided biopsy and histopathology assessment. The present examination was directed on 200 patients with central liver sores, There was a profoundly factually critical distinction (P-esteem < 0.001) between essential harmful gathering and generous injuries bunch as respect SWE of central injury, SWE of liver and FL/liver proportion. Exceptionally factually noteworthy distinction (P-esteem < 0.001) between essential harmful and metastatic gatherings as respect SWE of central sore and FL/liver proportion. SWE had the option to separate the essential danger from amiable injuries and metastases, as there was exceptionally factually huge distinction as respect SWE perusing of FL/liver proportion (P value<0.001).

(35.66 ± 17.32 and 2.74 ± 4.36 U/ml, respectively

Background: Hepatocellular carcinoma is a worldwide health problem . It is considered the second most common cause of cancerassociated fatalities and it is the fifth major cause of cancer all over the world. Cluster of differentiation 166 is a cell surface member of the immunoglobulin super-family that plays an important role in many biological activities. The distribution of CD166 in specific cell and tissue offer their involvement in the maintenance and development of tissue architecture, in neurogenesis and in tumor progression . Aim and objectives : to evaluate the diagnostic value of serum-CD166 in patients with HCC. Methods: This study was conducted on 90 subjects attending Department of Hepatology , Gastroenterology and Infectious Diseases in Benha University Hospitals as a cross sectional study. Subjects were classified into three groups; Group I : included 35 patients with HCC, Group II: included 35 patients with liver cirrhosis, Group III: included 20 apparently healthy subjects served as a control group. Human CD166 and alpha fetoprotein were assessed in all groups , all laboratory investigations were done . Results: Serum CD166 concentrations were much higher in HCC than in cirrhosis and healthy individuals . A positive correlation was found between serum CD166 and AFP. The area under the ROC curve for serum-CD166 was 0.951, while in AFP (AUC-ROC, 0.943) , with a cut-off of 1357ng/ml (sensitivity: 94.3%, specificity: 97.1%) for CD166 . Conclusion : Serum CD166 may represent a potential diagnostic marker for HCC .