We performed a retrospective study that analyzed serum samples from 60 patients diagnosed with de novo DLBCL, SummaryCirculating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0AE009, 0AE02 and 0AE04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0AE05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.

No abstract

No abstract