Polymer carrier with biodegradable, biocompatible as well as solubility enhancing properties are highly looked upon in the pharmaceutical industry to improve the drug delivery systems. A series of hyperbranched poly(glycerol esteramide) (HPGEA) with M w of 5000-12,000 Da, degree of branching of 57%-62%, and hydroxyl values of 200-280 mg KOH/g sample were synthesized through polycondensation of N,N-bis(2-hydroxyethyl)stearamide (diethanolamide) and poly(glycerol ester) (PGE). The HPGEAs were characterized by ATR-FTIR, GPC, 1 H and 13 C-NMR, and DSC. The enthalpy of fusion of HPGEAs (43-84 J g −1) were lower than the commercial polymers (193-391 J g −1), indicating its potential as drug carrier for solid dispersion (SD). HPGEA-based SDs showed substantial enhancement in solubility and release rate than pure drug, commercial polymer-based SDs, as well as commercial formulation. The safety of HPGEAs and HPGEA-based SDs were proven through MTT assay with IC 50 of 2400-9800 and 1200-3500 μg ml −1 , respectively.
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