A novel molecularly imprinted polymer (MIP) based electrochemical sensor was developed for differential pulse voltammetric detection of silodosin (SLD), used for enlarged prostate (benign prostatic hyperplasia; BPH) treatment. A computational design was first applied for optimization of the molar ratio between silodosin (SLD, template): Methacrylic acid (MAA, functional monomer), based on which five polymeric ratios were prepared followed by testing the amount of crosslinker (ethylene glycol dimethacrylate (EGDMA)), imprinting and rebinding efficiency of the polymer. The ratio 1:4:20 was found to have the highest binding capacity for SLD, and thus, was used as a modifier for the development of modified carbon paste electrodes in presence of multiwalled carbon nanotubes (MWCNT). The sensor was electrochemically characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements and morphologically using SEM, TEM and BET and its performance was optimized in terms of amounts of MIP, MWCNT, pH and other electrochemical parameters. A linear response range of 1.0 × 10 À 12 -1.0 × 10 À 3 M SLD with a detection limit (S/N = 3) of 1.0 × 10 À 13 M was shown. Finally, the MIP-modified carbon paste sensor was successfully used to determine SLD in pure solutions, pharmaceutical formulations and spiked serum and urine samples.

Background: Cow milk protein (CMP) is the most common cause of food allergy in infants and young children. CMP allergy (CMPA) can affect more than one system, such as the skin, respiratory, or digestive systems.  Gastrointestinal tract manifestations are nonspecific. One of the most important GI manifestations of CMPA is bloody stool. Purpose: This study aims to describe how many infants with GI manifestations of CMPA presented with bloody stool as it was a very annoying symptom to the family and describe how can be managed adequately. Methods: This study included 100 patients with gastrointestinal manifestations of CMPA, their ages ranged from 8 weeks to 2 years.  52 males and 48 females. All study patients were subjected to complete history, thorough clinical examination, imaging necessary, and laboratory investigations Results: bloody diarrhea was recorded in 23 patients, and 2 of them were diagnosed with food protein-induced enterocolitis syndrome (FPIES). Occult blood was detected in 11 patients in the diarrhea group (33.33%), 17 patients in the GER group (47.2%), and was detected in 5 patients (83.33%) who presented constipation associated with massive abdominal distension.

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BackgroundCommunity-acquired pneumonia (CAP) is one of the most common global health issues. Even though many vaccinations and new diagnostic tools are available, CAP has a higher mortality rate, especially in children less than five years of age. Complicated CAP (CCAP) in a healthy child is a severe disease characterized by a combination of local complications, such as parapneumonic effusion (PPE), empyema (EMP), necrotizing pneumonia (NP), abscess, pneumothorax, and bronchopleural fistula, and systemic complications, such as bacteremia, metastatic infection, multiorgan failure, acute respiratory distress syndrome, disseminated intravascular coagulation, and, rarely, death. This study describes the demographic features, clinical presentation, management, and outcomes of patients diagnosed with CCAP at the Al Qassimi Women's and Children's Hospital (AQWCH). MethodologyThis retrospective chart review aims to collect and explore the data of all previously healthy children admitted with CCAP between the ages of one month and 13 years at AQWCH from January 2018 to December 2020. The primary study outcome measure is to provide clinicians with the diagnostics, evaluation, and management required to treat complicated pneumonia.