Background: Family caregivers of children with chronic kidney disease face many challenges in managing illness. So, the burden impact on physical, emotional, spiritual and social health. The aim of this study was to determine the effect of practical guides for burden's coping strategies intervention with caregivers of chronic hemodialysis children on their burden. Methods: Subjects: A convenient sample compromised 50 caregivers of chronic hemodialysis children were selected, in hemodialysis units at The Menofuia University Hospital at Shebin El-kom city, Menoufia Governorate, Egypt and Tanta University Hospital at Tanta city, El-karbeia Governorate, Egypt. Instruments: It consisted of three tools; 1) questionnaire for socio demographic data. 2) Paediatric Renal Caregiver Burden Scale (PR-CBS). 3) Ways of coping questionnaire. All tools were used for pre-post intervention. The results: The study showed regarding to total burden scores, there was a highly statistically significant reduction in total burden scores after intervention (97.54 ±13.51) compared with (120.02 ±16.34) before intervention. Regarding total coping scores, there was highly statistically significant improvement in total coping scores after intervention (58.86 ±6.65) compared with (51.66 ±8.81) before intervention. Conclusion: the application of practical guides for burden's coping strategies intervention with caregivers of chronic hemodialysis children reduced their burden and has succeeded in achieving significant improvement in caregivers' coping strategies. Recommendations: implementation of practical guide for burden's coping strategies intervention for all caregivers' chronic disease patients.
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