Plant diseases accounts for huge losses in agriculture. To ensure food security and sustainability, an agricultural yield must be improved to meet the growing world population. Due to growing awareness of the effect of pesticides and herbicides on human health and the environment, an alternative safe method of controlling phytopathogens has become a subject of intense research. Biological control of plant diseases is the use of living organisms to suppress or inhibit plant pathogens. Microbiological control agents (MBCAs) employ microorganisms to protect crops from destruction by phytopathogens through different modes of action. They may act by direct interaction with the pathogens through hyperparasitism. Indirect antagonistic interaction with the pathogen through induction of host resistance and priming is another mode of attack by MBCAs. Competition for nutrients and space is another important indirect mode of attack by which MBCAs suppress the growth of pathogens through nutrient deprivation. The MBCAs can also interact with the plant through secretion of antibiotics or antimicrobial secondary metabolites with inhibitory effect against the pathogens. A clear understanding of the mode of action of MBCAs is vital to achieving a successful biocontrol operation as well as improving the biocontrol process that is devoid of risks to humans and the environment. Such improvement could be achieved through the use of microbial consortia to enhance the stability and efficiency of the biocontrol process. Further studies on aspects of mass production and formulation to produce more effective, stable, safer and cost effective MBCAs are needed.
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