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Post-polypectomy syndrome is a rare complication of polypectomy with electrocautery and is characterized by a transmural burn of the colon wall. Patients typically present within 12 hours after the procedure with symptoms mimicking colonic perforation. We present the case of a 45-year-old female who developed abdominal pain seven hours after colonoscopy during which polypectomy was performed using electrocoagulation. CT imaging of the abdomen revealed circumferential thickening of the wall of the colon without evidence of free air. The patient was treated conservatively as and had resolution of his pain over the following days. Recognition of the diagnosis and understanding of the treatment are important to avoid unnecessary exploratory laparotomy or hospitalization.