No abstract

A series of O-benzyl-N-(9-acridinyl)hydroxylamines was prepared, isolated, and evaluated for biological activity using both thermal denaturation and MTT assays. Changes in the thermal denaturation temperature of genomic calf-thymus DNA ranged from +6.6 °C to +20.2 °C. MTT assays on SNB-19 glioblastoma cells provided biological activity that ranged from 17.4 µM to 33.2 µM. Both evaluation methods of biological activity indicate that substitution of the benzyl group by either electron-withdrawing or electron-donating groups provides a measureable benefit in these assays. The two assays agreed on the magnitude of the interaction for each substitution pattern.

Im Gegensatz zu früheren Angaben führt die Bromierung von 2‐Phenyl‐2‐methallylindan‐1,3‐dion (I) zum Bromhydrin (II), das mit Piperidin zum Aminoalkohol (III) reagiert.