Aims: An experiment was conducted to evaluate the anti-inflammatory effects of ethanolic bark extract of Plumeria obtusa. Material and method: Anti-inflammatory activity was evaluated by using two different animal models namely cotton pellet method and carrageenan induce paw edema in male Wistar rats at a dose of 100,200 and 400 mg/kg respectively. Results: Phytochemical examination of the extract exposed the existence of alkaloids, flavonoids, tannins and terpenoids. The ethanolic extract elicited highly significant (p<0.001) inflammatory activity in a dose dependent manner on cotton pellet method and carrageenan induce paw edema method. This was noticed by prominently decrease of paw volume in carrageenan induce paw edema and marked increase in % inhibition of cotton pellet Granuloma pouch at the dose of 100,200 and 400 mg/kg respectively. Conclusion: The present investigations showed that the ethanolic extract Plumeria obtusa stem bark has potential anti-inflammatory activity when screened on carrageenan-induced paw edema and cotton pellet Granuloma pouch models in rats.
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