The present study included seroprevalence detection of Toxoplasma gondii in human and chickens (Gallus domesticus) in AL-Door district, Salahdin province, and the histological effects of T. gondii on some of internal organs (brain, kidneys, liver and muscles) from chickens. Positive seroprevalence result for human toxoplasmosis was recorded 22.3% with highest prevalence for positive IgG that reported 14.1%. Based on gender, significant increasing was recorded for toxoplasmosis in males 27.3% when compared with female 12.7%, while according to age, significant variances were reported among the age groups, the highest seroprevalence was 27.8% in age group 31-40 years. For seroprevalence of chicken toxoplasmosis, the percentage of positive results was 66.7%. Different histological effects were recorded in the current study such as congested blood vessels in the brain cortex tissue with vacuolation in the outer regions of brain, atrophied glomeruli in the renal cortex, masses of hepatocytes with presence of Kupffer cells, also cellular aggregation of fibroblast and WBCs in muscles.
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