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Background: Obesity is a medical condition in which excess body fat has accumulated to extend that it may has an adverse effect on health. Leading to reduction of life expectancy or increasing health problems.Objective: To evaluate the improvement in plasma glucose level and lipid profile in type 2 diabetes mellitus obese patients after Laparoscopic Sleeve Gastrectomy (LSG).

The successful treatment rate of Helicobacter pylori is facing many challenges, mainly due to antimicrobial resistance as a result of antibiotics abuse. To assesse the burden of resistance-associated treatment failure, the efficacy of culture-based antimicrobial susceptibility was tested for all antimicrobial used as treatment guidelines for eradication of Helicobacter pylori infection. Methods: In this study, incidence of Helicobacter pylori infection in Minia University hospital was determined by testing a random sample of 40 patients undergoing upper gastrointestinal endoscopy for Helicobacter pylori infection. Then, the agar dilution method was used to determine the minimal inhibitory concentration of 6 alternative antibiotics, patterns of antimicrobial resistance and efficacy of commercial antibiotics in treatment of Helicobacter pylori infection. Results: Prevalence of Helicobacter pylori infection was 47.5% among our patients. Antibiotic resistance rates were alarmingly high, up to 100% in amoxicillin, rifampicin, and levofloxacin, 94.7% in tetracycline and clarithromycin, and 89.4% in metronidazole. Discussion: This Study showed unprecedented antimicrobial resistance rates of Helicobacter pylori. New alternative treatment regimens should be considered and investigated to replace the current ineffective therapies.