Reactions of tetrafluoropyridazine (1 ) with gaseous thiocarbonyl difluoride or its liquid trimer, viz. bis(trifluoromethy1) trithiocarbonate, in the presence of caesium fluoride yield, selectively, 3,4,6trifluoro-5-trifluoromethylthiopyridazine (2) or 3,6-difluoro-4,5-bis(trifluoromethylthio)pyridazine(3) depending on the reactant ratio; with an excess of the CF,Sion source a small amount of 3f I uoro-4,5,6tris( trif luoromet hylt hio) pyridazine (4) was formed. The reactions of tetraf luoropyrimidine (5) proceeded unselectively to give mixtures of 2,4,5-trifluoro-6-trifluoromethylthiopyrimidine (6), 2,4-difluoro-5,6-bis(trifluoromethylthio)pyrimidine (7), 2,5-difluoro-4,6-bis(trifluoromethylthio)pyrimidine ( 8 ) , and in some cases 5-fluoro-2,4,6-tris(trifluoromethylthio)pyrimidine (9). The new trifluoromethylthio derivatives of pyridazine and pyrimidine have been characterized by b.p., 19F n.m.r., and m.s. data.
In conclusion, it can be said that the book succeeds in providing a really useful survey of methods for the preparation of organic compounds. It is of great practical value, and should soon become a standard work for the organic laboratory.H . Stetter [W f 6 IE]
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.