Background Retinopathy of prematurity (ROP) is a significant morbidity in preterm babies. Multiple risk factors for severe ROP have been extensively studied, however, only a few studies have included maternal diabetes mellitus (MDM) in their assessment. ROP and diabetic retinopathy are both retinal vascular diseases in which there is leakage and/or neovascularization from damaged retinal vessels. Diabetes may affect ROP development; however, there are conflicting results on the association between MDM and ROP. Objective To determine if MDM is an independent risk factor for clinically significant ROP (ROP > Stage II) in neonates weighing less than 1500g. Design/Method We conducted a retrospective cohort study of neonates weighing <1500g who were delivered or transferred into our institution from 2007 through 2017. Logistic regression was used to analyze the association between severe ROP and MDM. The risks for the different stages of ROP from MDM were compared using chi-square linear trend test. Results We extracted 883 paired maternal-neonatal data. The mean (standard deviation) gestational age and birthweight were 28.5 (2.9) weeks and 1052.7 (300.9) grams, respectively. Of the 883 mothers, 72 (8.2%) had DM. The incidence of ROP and severe ROP was 42.4% (374/883) and 6.5% (57/883) respectively. The odds ratio comparing MDM and severe ROP was 3.47 [95% CI: 1.51-7.96]; p<0.01). Compared to Stage I, the risk of MDM in infants with ROP increased from 1.49 in Stage II ROP to 2.59 in Stages III&IV. Severe ROP was
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a global pandemic, with many cases affecting the elderly. However, children have been affected as well, with about 2.4-3.7% of cases reported. This case is the first published case of an adolescent presenting with rhabdomyolysis as the first sign of COVID-19, with extremely elevated creatinine kinase (CK) levels, approaching almost 400,000 U/L. This case adds to the growing body of literature of a variety of life-threatening manifestations associated with SARS-CoV-2 infection, and highlights the importance of how prompt recognition of these unique presentations of the disease is important to mitigate complications.
Herbaceous perennials comprise one of the fastest-growing segments of floriculture crop production. Little information has been published regarding their mineral nutrition requirements, specifically nutrient foliar standards and nutrient deficiency symptoms. Our research documents visual symptoms of nutrient deficiencies in the chronological order in which they appear from incipient to advanced stages, and establishes foliar analysis standards by correlating nutrient levels with initial and advanced stages of symptoms for nitrogen, phosphorus, potassium, calcium, magnesium, sulfur, iron, copper, zinc, manganese, molybdenum, and boron. Rooted cuttings were grown for as many as 12 weeks in a hydroponic system with modified Hoagland's solution minus the element of interest, along with complete nutrient solution controls. Taxa selected for study were representative of commonly grown varieties and of differing families; Verbena canadensis `Homestead Purple' (clump verbena), Heliopsis helianthoides `Bressingham Doubloon' (false sunflower) and Veronica × `Goodness Grows' (speedwell). Days to incipient deficiency symptoms ranged from 5 to 60. Chronological order of appearance was consistent with Fe and Ca symptoms appearing within 10 days for all three taxa. Other deficiency symptoms varied both by taxa and in chronology. Root and shoot dry weights were closely and positively correlated with time to incipient deficiency.
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