Ozone in the troposphere can cause plant stress, whereas elevated CO. generally causes positive responses. Little is known of how these gases interact to affect plant response. Interactive effects on yield and seed quality of soybean [Glycine max (L.) Merr.] grown in 14-L pots were measured in open-top field chambers. Essex was tested in 1993, and Essex, Holladay, and NK 6955 were tested in 1994. Plants were exposed from emergence to maturity to four CO; levels (ambient and 1.3,1.6, and 2.0 times ambient) and three O, levels (0.4, 0.9, and 1.5 times ambient) in 12 combinations. Increasing O, suppressed growth and yield, whereas CO, enrichment stimulated growth and yield. Carbon dioxide-induced stimulation was greater for plants stressed by O, than for non stressed plants. For example, CO 2 at 2.0 times ambient increased 2-yr mean seed yield of Essex by 16, 24, and 81% at O, levels of 0.4, 0.9, and 1.5 times ambient, respectively. Effects of O, and CO, on seed oil content were variable with numerous cultivar differences. Seed protein content was never affected. Elevated O, suppressed oleic acid content in seeds, whereas CO, increased it; the nature of the O, x CO 2 interaction for oleic acid was similar to that observed for most yield measures. Carbon dioxide-induced stimulation of plants stressed by O, was apparently caused partly by amelioration of O 3 stress. Interactions between O 3 and CO 2 must be considered for proper interpretation of cause-effect relationships in CO, enrichment studies.