The acetylation rate of sulfamethazine was studied in 25 patients with systemic lupus erythematosus (SLE). Seventeen of 25 SLE patients, 6896, were slow acetylators compared to the reported incidence of 52% in the general population. There was no correlation between the acetylator phenotype in SLE patients and the various clinical manifestations or the activity of the disease. Lupus patients who were slow acetylators had a lower lymphocyte response to phytomitogens compared to rapid acetylators.Following the administration of certain drugs, a number of patients develop a disease which presents many of the clinical and laboratory characteristics of systemic lupus erythematosus (SLE). The drugs most clearly associated with this lupus-like syndrome are hydralazine, procainamide, anticonvulsants, and isoniazid (1 ). Prolonged therapy with hydralazine, a frequently used antihypertensive agent, induces antinuclear factors (ANF) in 54% of patients (2). Approximately 12% of
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.