No abstract

No abstract

It is well established that normal men and women excrete estrogenic and androgenic substances in the urine. Qualitatively speaking, it is also well established that at least a part of the androgenic activity in men's urine is due to androsterone and dehydro-androsterone (1, 2, 3), but There is somewhat better agreement on the daily excretion of estrogenic activity in women, but practically no data on the excretion in men. Siebke (6) first reported 0 to 180 mouse units per liter of women's urine throughout the cycle. From studies on eight normal women he concluded that there is a low excretion previous to and during menstruation. Later Siebke (11) reported 10 to 140 mouse units of estrogenic activity per liter of urine in women with a distinct rise between the 10th to the 15th day of the cycle. Frank (12) reported 20 to 320 mouse units per day with peaks at 12 to 15 days after the onset of menstruation and 4 to 8 days before the next bleeding. Biihler (8) reported 10 to 60 mouse units per day in normal men. Gustavson and Green (13) and Smith and Smith (14) also report two peaks in the excretion of estrogenic activity in women during the menstrual cycle. The former find 0 to 50 rat units per day with peaks at the 9th to 14th day and the 14th to 21st day after menstruation. Smith and Smith (14) record the peaks at 12 to 17 days after menstruation and during menstruation.In this paper we present our methods of extraction and assay in detail and the results on four normal men and four normal women for 27 to 45 consecutive days. The male urine was collected 695

No abstract

No abstract