Activities of hepatic "regulatory" glyeolytic and gluconeogenic enzymes were assayed in obese-hyperglycemic mice and were found to be elevated over those observed in lean littermates. Qualitatively similar results were obtained when goldthioglucose-obese mice were compared with untreated controls. It therefore appears that these alterations of enzyme activity are not unique to the obese-hyperglycemic syndrome but reflect metabolic disturbances related to obesity per ae. The unexpected elevation in the activities of the glueoneogenic enzymes are discussed. Glycolytie enzyme activity assayed in heart and striated muscle revealed no differences
Gelfand's hypothesis stating that pain threshold and pain tolerance have different loadings of physiological and psychological components was investigated. Specifically it was postulated that nonpermissive instructions (suggestion) should significantly increase pain tolerance compared to permissive instructions (no suggestion), but that there should be no significant changes in pain threshold. 34 healthy Ss were divided randomly into 2 equal groups. 1 started with permissive and the other with nonpermissive instructions using electrical stimulation, and after 5 trials instructions were reversed in both groups. The results supported the hypothesis for ascending pain threshold and pain tolerance, but not for descending pain threshold. The latter was explained by suggesting that pain relief is an emotional state interfering with sensory discrimination.
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