Abdominal circumference measurements were useful in screening for suspected macrosomia. An AC measurement of 35 cm or more identified more than 90% of macrosomic infants who were at risk for shoulder dystocia. Induction of labor in macrosomic patients increased the risk of shoulder dystocia.
SUMMARY Since both ghicocortkoids and catecholamines are involved in the regulation of normal blood pressure, we Investigated the modulation of /3-adrenergic receptors of cultured rat arterial smooth muscle cells by glucocorticoids. The synthetic glucocorticoids dexamethasone and RU 28362, at 10~8 M concentration, increased maximum 0-adrenergic binding but had no effect on the dissociation constant (£d). Each steroid caused an Increase hi maTimnm [^dihydroalprenolol binding over the concentration range of 10~8 to 10"* M, but not at 10~9 M. The glucocorticoid effect on /3-adrenergk receptors of arterial smooth muscle cells required a minlmnm of 20 hours of incubation in the presence of the steroid and was significantly inhibited by cycloheximlde (10 Mg/ml), indicating that the glucocorticoid effect required protein synthesis. The effect of dexamethasone on [ and rat lung. 4 Glucocorticoids are also involved in the regulation of agonist-mediated )3-adrenergic response in human neutrophils.56 Both glucocorticoids and catecholamines are involved in the regulation and maintenance of normal blood pressure. 78 Synthetic glucocorticoids have been shown to augment pressor response to angiotensin II and norepinephrine, and this effect is blocked by glucocorticoid antagonists.9 In addition, in Cushing's syndrome, the pressor response to angiotensin II and norepinephrine is elevated.
10Our laboratory has previously shown that cultured rat arterial smooth muscle cells (ASMCs) contain
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