Introduction This study explored the prevalence of depression among the patients with chronic kidney disease and their caregivers and its association to their demographic profile. Methods A descriptive, correlational, cross-sectional study that used the Hamilton rating scale tool to assess the prevalence of depression among 226 patients undergoing hemodialysis and 105 of their caregivers in a hospital in Saudi Arabia. Results Patients with chronic renal disease and their caregivers experience depression at varying levels. Depression was positively associated with the socioeconomic and marital status of the patients. Socioeconomic status of the caregivers was seen to be associated with their depression. Conclusion Depression is highly prevalent among patients with chronic renal disease and their caregivers.