Amidate ligands have been used as a modular ligand set for early transition-metal complexes, and have been found to exhibit high reactivity in the catalytic hydroamination of alkynes, allenes, and alkenes. This microreview focuses on coordination metal complexes containing amidate functionality including their bonding, structure and reactivity trends. The
Substituted pyrimidinols, acidic aromatic alcohols, were used as proligands to synthesize metal
complexes of Ti and Zr. These new pseudotetrahedral complexes were investigated as catalysts for the
hydroamination of alkynes and alkenes. The stabilized anion of the pyrimidinoxide ligand results in
enhanced electrophilicity at the metal center. These electronically modified complexes are catalytically
active, but their enhanced reactivity results in reduced selectivity in comparison with the related bis(phenoxide) complexes in alkyne hydroamination. This reactivity was used to advantage in the
cyclohydroamination of select aminoalkene substrates with the Zr bis(pyrimidinoxide) complex.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic hydroamination is combined with the Strecker reaction to yield a one-pot synthesis of a-cyanoamines from terminal alkynes. This methodology is further applied to the synthesis of a-amino acids and a-amino esters.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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