This third and final ‘Geographies of food’ review is based on an online blog conversation provoked by the first and second reviews in the series (Cook et al., 2006; 2008a). Authors of the work featured in these reviews — plus others whose work was not but should have been featured — were invited to respond to them, to talk about their own and other people’s work, and to enter into conversations about — and in the process review — other/new work within and beyond what could be called ‘food geographies’. These conversations were coded, edited, arranged, discussed and rearranged to produce a fragmentary, multi-authored text aiming to convey the rich and multi-stranded content, breadth and character of ongoing food studies research within and beyond geography.
The past few decades have seen many studies that ‘follow-the-thing’ by tracing an object back to its origins. In carrying out my own thing-following, however, I found the objects I chose were at times unfollowable, their trajectories highly changeable and punctuated by numerous ruptures. This article explores how we might progress with a methodology born in an age of early globalisation, when tracing things was easier and more surprising than today. It suggests that attempting to understand the unfollowable bits of the commodity trail may be an apposite way to go about such studies, especially in the light of the fact that globalisation is now a well-established phenomenon and capitalism’s precarious nature shows no sign of abating.
Small heteroaryl‐diyne (Het‐DY) tags with distinct vibrational frequencies, and physiologically relevant cLog P were designed for multiplexed bioorthogonal Raman imaging. Pd−Cu catalyzed coupling, combined with the use of Lei ligand, was shown to improve overall yields of the desired heterocoupled Het‐DY tags, minimizing the production of homocoupled side‐products. Spectral data were in agreement with the trends predicted by DFT calculations and systematic introduction of electron‐ rich/poor rings stretched the frequency limit of aryl‐capped diynes (2209–2243 cm−1). The improved Log P of these Het‐DY tags was evident from their diffuse distribution in cellular uptake studies and functionalizing tags with organelle markers allowed the acquisition of location‐specific biological images. LC–MS‐ and NMR‐based assays showed that some heteroaryl‐capped internal alkynes are potential nucleophile traps with structure‐dependent reactivity. These biocompatible Het‐DY tags, equipped with covalent reactivity, open up new avenues for Raman bioorthogonal imaging.
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