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Background:To predict the behavior of biological systems, mathematical models of biological systems have been shown to be useful. In particular, mathematical models of tumor-immune system interactions have demonstrated promising results in prediction of different behaviors of tumor against the immune system.Methods:This study aimed at the introduction of a new model of tumor-immune system interaction, which includes tumor and immune cells as well as myeloid-derived suppressor cells (MDSCs). MDSCs are immune suppressor cells that help the tumor cells to escape the immune system. The structure of this model is agent-based which makes possible to investigate each component as a separate agent. Moreover, in this model, the effect of low dose 5-fluorouracil (5-FU) on MDSCs depletion was considered.Results:Based on the findings of this study, MDSCs had suppressive effect on increment of immune cell number which consequently result in tumor cells escape the immune cells. It has also been demonstrated that low-dose 5-FU could help immune system eliminate the tumor cells through MDSCs depletion.Conclusion:Using this new agent-based model, multiple injection of low-dose 5-FU could eliminate MDSCs and therefore might have the potential to be considered in treatment of cancers.

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To estimate the absorbed dose in normal organs and inflamed tissue following i.v. administration of [201Tl](III)-DTPA-HIgG by using biodistribution data in inflamation bearing rats was attempted. The percentages of injected dose per gram of each organ were calculated. The medical internal radiation dose formulation was applied to calculate the absorbed dose for various organs. The inflamed tissue to blood activity concentration ratios were about 19 and 23.3 at 24 and 28 h post-injection, respectively. A 185-MBq injection of 201Tl-DTPA-HIgG into the human body, might result in an estimated absorbed dose of 14.4 mGy for the total body and the highest absorbed dose was in the kidney with 1195 (mGy) and second to the Spleen were the liver, the lungs and the adrenals, which received 250.5 (mGy), 58.64 (mGy) and 56.44 (mGy), respectively. Biodistribution of [201Tl](III)-DTPA-HIgG demonstrated significant inflamed tissue uptake and low muscle and blood uptake, allowing for imaging of inflamed tissues.

Purpose: In some gamma spectroscopy experiments, neutrons may also be present, so depending on experimental conditions, Gamma spectroscopy can be influenced by the presence of neutrons. Materials and Methods: In this study, a NaI(Tl)(63 mm×63 mm) detector is used to investigate the effects of fast neutrons on the spectrum of gamma photons. The radiation source used in these experiments is made up of two point sources: an AmBe (50 mCi) neutron source and a 137Cs(10 mCi) gamma source. Results: Results were determined through both measurements and Monte Carlo simulation (MCNPX) under two different experimental conditions and were compared. When the detector is placed under an angle to the source, gamma photon energy peaks resulting from inelastic interactions of the fast neutrons with the detector materials and surrounding materials in the energy range of 0.1-0.9(MeV) are pretty visible in the gamma main spectrum. These results can be used to optimize industrial tomography experiments carried out with NaI(Tl) scintillators. Conclusion: Also, the results show that the detection of fast neutrons with a NaI(Tl) scintillator is possible with low efficiency.