Coronavirus disease 2019 (COVID-19), with high-transmission power, is spreading rapidly, and researchers are endeavoring to discover eligible medications for its efficacious prevention and treatment globally. According to the World Health Organization (WHO) reports, several multicenter clinical trials are launched to determine effective treatment protocols against COVID- 19-associated pneumonia. In this article, we aimed to discuss some critical issues concerning novel coronavirus.

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Cervical collar applications in trauma patients cause a significant decrease in lung capacity and spirometry parameters. Patients suffering from lung diseases and respiratory distress require special attention which means that the cervical collar should be removed as soon as cervical injuries are ruled out so as to avoid hypoxia.

The recent emergence of corona virus disease-2019 (COVID-19), demonstrates the pandemic potential of COVID-19, the rapid spread of this virus across the world in only a few months highlights the transmissibility of this disease and the significant morbidity and mortality that it can cause, And these reasons make the importance of triage even more colorful at this point.Thus, we designed the principles for better emergency department triage of these patients and reducing the possible risks of transmitting this disease. We hope that with this study, we will be able to partially solve the triage problems of these patients and the problems of the health care staff.

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Introduction: Despite a high burden of traffic injuries, effective integrated or linked injury surveillance systems are rarely available in many low-and middle-income countries (LMICs). The aim of the current study was to define a conceptual model for developing a national integrated traffic injury registry in Iran. Methods: A mult-method study financially and technically supported by the World Health Organization, Iranian Ministry of Health, Iranian Traffic Police, and the Iranian Legal Medicine Organization was conducted. A theoretical framework, forming the core conceptual components, was developed based on expert reviews. The preliminary conceptual model was developed by a panel of experts and tailored through a national workshop of 50 scientists, authorities and experts from nearly all sectors related to road safety promotion and injury management. It was then sent out to external reviewers in order to assess and improve the content validity of the model. Results: The conceptual model was developed to have six components. These included 1) aims and core definitions; 2) content and core measurements; 3) data flow; 4) data collection routines; 5) organizational matrix; 6) implementation organization. The Haddon's matrix was adapted to be used as the theoretical framework in defining the content and data flow components of IRTIR. Five subcomponents were defined in the content and core measurements component with each having several subcategories. Each subcomponent/subcategory was finally divided into several item groups to guide defining the final data measurement variables. The data flow component was defined with six data sequence stations. Through the organizational matrix component, five major organizations relevant to road traffic safety were defined as core data production contributors. Some organizations also owned several sub-organizations which contributed in this regard. Conclusion: It is concluded that the IRTIR conceptual model includes the required six components for developing a national integrated registry for Iran. Its main component called, content and core measurements, leads the researchers in developing final data collection tools in developing the national registry of road traffic injuries in Iran.

Background: There are many concerns about the migration of phthalates into bottled water. These compounds are hazardous to consumers. In this study, the risk factors of the use of various brands of drinking water bottled in polyethylene terephthalate (PET) containers under different storage conditions were examined. Methods: Phthalate esters were measured and analyzed using air-assisted liquid-liquid microextraction (AALLME) and gas chromatography-mass spectrometry (GC-MS). Subsequently, the risk of exposure to the desired compounds was evaluated by calculating the risk factor and excess cancer risk. Data were statistically analyzed using SPSS version 24 software. Results: The average concentration of phthalate esters (DEHP, DBP, DIBP, DEP, and DMP) after 5 and 15 days of storage at incubator temperature of 42°C, and after 15, 45, and 75 days at incubator temperature of 25°C by increasing the initial level of the conditions was 7.28, 8.99, 1.78, 5.6, 6.45, and 8.55 ppb, respectively. The risk factor of non-carcinogenic effects of phthalates for consumers was low and can be ignored (HQ<1). Also, the risk of additional cancer due to the presence of diethylhexyl phthalate (DEHP) in bottled water is very low (4.8551×10-6). Conclusion: However, due to the increase in the concentration of phthalate esters in bottled water by increasing the storage time and temperature, as well as increasing the ethylene hexyl phthalate content from its established limit, the use of bottled water kept in unsuitable conditions for the society, and especially the sensitive groups, is not appropriate

Background Neurological involvements of COVID-19 are one of the most reported manifestations of this infection. This study aims to systematically review the previous systematic reviews which addressed the neurological manifestations of the COVID-19 infection. Methods Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, a comprehensive search was conducted in PubMed, Embase, Scopus, Web of Science databases and Google Scholar from December 2019 to December 2020. Articles were critically screened by two independent reviewers and if met the inclusion criteria, entered the study. Assessment of methodological quality was conducted by Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool. Statistical analysis was not applicable. From a total of 1302 studies, 308 studies were removed due to their irrelevant title and abstract. After screening the full texts, a total of 66 found to be eligible. Twenty-one studies reported general manifestations of the COVID-19, 13 studies reported cerebrovascular events, 19 olfactory and oral dysfunctions, 5 systematic reviews on Guillen–Barré syndrome (GBS) and 8 articles on the sporadic manifestations like ocular signs and symptoms. The majority of the studies were classified as critically low or low in terms of quality. Conclusion Despite great heterogeneity in the current literature, neurological involvements are an important extra-pulmonary aspect of the COVID-19; most commonly in the form of general manifestations like headache and olfactory disturbances. Long-term effects of this virus on the nervous system must be a research priority for future references.