Thermal stability,
structural evolution pathways, and phase transition
mechanisms of the calcium oxalates whewellite (CaC2O4·H2O), weddellite (CaC2O4·(2+x)H2O), and caoxite
(CaC2O4·3H2O) have been
analyzed using single crystal and powder X-ray diffraction (XRD).
During single crystal XRD heating experiments, α-CaC2O4 and the novel calcium oxalate monohydrate have been
obtained and structurally characterized for the first time. The highest
thermal expansion of these compounds is observed along the direction
of the hydrogen bonds, whereas the lowest expansion and even contraction
of the structures occur due to the displacement of neighbor layered
complexes toward each other and to an orthogonalization of the monoclinic
angles. Within the calcium oxalate family, whewellite should be regarded
as the most stable crystalline phase at ambient conditions. Weddellite
and caoxite transform to whewellite during dehydration-driven phase
transition promoted by time and/or heating.
Single crystals and powder samples of uric acid and uric acid dihydrate, known as uricite and tinnunculite biominerals, were extracted from renal stones and studied using single-crystal and powder X-ray diffraction (SC and PXRD) at various temperatures, as well as IR spectroscopy. The results of high-temperature PXRD experiments revealed that the structure of uricite is stable up to 380 °C, and then it loses crystallinity. The crystal structure of tinnunculite is relatively stable up to 40 °C, whereas above this temperature, rapid release of H2O molecules occurs followed by the direct transition to uricite phase without intermediate hydration states. SCXRD studies and IR spectroscopy data confirmed the similarity of uricite and tinnunculite crystal structures. SCXRD at low temperatures allowed us to determine the dynamics of the unit cells induced by temperature variations. The thermal behavior of uricite and tinnunculite is essentially anisotropic; the structures not only expand, but also contract with temperature increase. The maximal expansion occurs along the unit cell parameter of 7 Å (b in uricite and a in tinnunculite) as a result of the shifts of chains of H-bonded uric acid molecules and relaxation of the π-stacking forces, the weakest intermolecular interactions in these structures. The strongest contraction in the structure of uricite occurs perpendicular to the (101) plane, which is due to the orthogonalization of the monoclinic angle. The structure of tinnunculite also contracts along the [010] direction, which is mostly due to the stretching mechanism of the uric acid chains. These phase transitions that occur within the range of physiological temperatures emphasize the particular importance of the structural studies within the urate system, due to their importance in terms of human health. The removal of supersaturation in uric acid in urine at the initial stages of stone formation can occur due to the formation of metastable uric acid dihydrate in accordance with the Ostwald rule, which would serve as a nucleus for the subsequent growth of the stone at further formation stages; afterward, it irreversibly dehydrates into anhydrous uric acid.
The effect of bacteria that present in the human urine (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus) was studied under the conditions of biomimetic synthesis. It was shown that the addition of bacteria significantly affects both the phase composition of the synthesized material and the position of crystallization boundaries of the resulting phosphate phases, which can shift toward more acidic (struvite, apatite) or toward more alkaline (brushite) conditions. Under conditions of oxalate mineralization, bacteria accelerate the nucleation of calcium oxalates by almost two times and also increase the amount of oxalate precipitates along with phosphates and stabilize the calcium oxalate dihydrate (weddellite). The multidirectional changes in the pH values of the solutions, which are the result of the interaction of all system components and the crystallization process, were analyzed. The obtained results are the scientific basis for understanding the mechanisms of bacterial involvement in stone formation within the human body and the creation of biotechnological methods that inhibit this process.
Chemically induced
polytypic phase transitions have been observed
during experimental investigations of crystallization in the mixed
uranyl sulfate-selenate Mg[(UO2)(TO4)2(H2O)](H2O)4 (T = S, Se) system. Three different structure types
form in the system, depending upon the Se:S ratio in the initial aqueous
solution. The phases with the Se/(Se + S) ratios (in mol %) in the
ranges 0–9, 16–47, and 58–100 crystallize in
the space groups P21, Pmn21, and P21/c, respectively. The structures of the phases are based upon the same
type of uranyl-based sulfate/selenate chains that, through hydrogen
bonds, are linked into pseudolayers of the same topological type.
The layers are linked into three-dimensional structures via interlayer
Mg-centered octahedra. The three structure types contain the same
layers but with different stacking sequences that can be conveniently
described as belonging to the 1M, 2O, and 2M polytypic modifications. The Se-for-S substitution
demonstrates a strong selectivity with preferential incorporation
of Se into less tightly bonded T1 site. The larger
ionic radius of Se6+ relative to S6+ induces
rotation of (T1O4) tetrahedra in the adjacent
layers and reconstruction of the structure types. From the information-theoretic
viewpoint, the intermediate Pmn21 structure
type is more complex than the monoclinic end-member structure types.
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