Early palliative care interventions are beneficial for patients with hematologic malignancies and bone marrow transplant processes. Better understanding of barriers to its implementation and development of creative initiatives is of paramount importance. New research endeavors should focus on providers' attitudes toward patients and communities.

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The care of patients with HIV and Burkitt lymphoma poses a challenge to clinicians. Due to the limited treatment options that exist for relapsed/refractory Burkitt lymphoma, there is a need for the development of new therapies. This review aims to discuss evidence for current management strategies including chemotherapy and stem cell transplant, and highlight gaps in knowledge that will need to be addressed in the future.

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease and is a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage. Methods: SH-SY5Y cells were stably transfected with plasmids containing wild type (WT) α-Syn and A53T mutant α-Syn as fusion proteins with EGFP and an EGFP only control vector. The cells were differentiated using retinoid acid (RA) and treated with hydrogen peroxide (H 2 O 2) and analysed in a differentiated state for the effects of oxidative stress using flow cytometry, DNA damage using γH2A.X staining and inflammatory and senescence markers using qPCR.

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The number of road traffic deaths continues to climb, reaching 1.35 million deaths globally in 2016 and road traffic injury is now the leading cause of death for children and young adults aged 5–29 years (WHO, 2018). Road safety is officially recognized as a global safety issue and it is also included in the Sustainable Development Goals. This is a questionnaire based analysis, which aims to understand the outlook of the general public regarding the current road safety system and to understand the level of awareness regarding the same. It also aims to compare the perspective of drivers and non-drivers towards traffic rules. Majority of the participants were from the age group of 15-30 years as they are most directly affected by road accidents. Our objective is to understand the shortcomings in the current road safety system through the perspective of the general public, which can then help in implementing a more efficient system in order to decrease the number of road accidents. Inadequate traffic system also significantly affects the economic growth of the region. According to the World Road Statistics, 2018, India ranks 1st in the number of road accident deaths hence there is an urgent need to understand the root cause for such a high number of accidents and to find solutions for this issue. Our results show that there is a need to implement stricter rules for road safety and this perspective of the general public is not affected by the status of the individual (driver, non-driver). It also suggests the need for increasing the level of licence tests conducted. Increasing awareness at an early stage among the people regarding the seriousness of following traffic rules can help prevent road accidents at the baseline level.