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Objective To analyze the impact of the color of a resin composite cement (RCC) on the optical properties of different computer‐aided design and computer‐aided manufacturing (CAD/CAM) ceramics. Materials and methods Specimens (N = 220, thickness: 0.9 ± 0.03 mm) were fabricated from: leucite (Initial LRF Block/IPS Empress CAD), lithium disilicate (Amber Mill/IPS e.max CAD), lithium metasilicate (Celtra Duo), and lithium alumina silicate ceramic (n!ce) in translucency levels HT and LT. All specimens were bonded with an RCC (Light+/Warm+). Color was analyzed (spectrophotometer) initially as well as after bonding of RCC with CAD/CAM ceramics using CIELab and CIEDE2000. Kolmogorov–Smirnov test, one‐way ANOVA and t test served for analyzing (α = 0.05). Results Highest impact on ΔE presented the choice of ceramic (ηp2 = 0.155/p < 0.001), followed by translucency level (HT/LT; ηp2 = 0.050/p = 0.001) as well as interaction between ceramic and translucency level (ηp2 = 0.175/p < 0.001). ΔE00 was mainly influenced by the choice of ceramic (ηp2 = 0.490/p < 0.001), the shade of resin composite (ηp2 = 0.031/p = 0.012) as well as the interaction between ceramic and resin composite (ηp2 = 0.258/p < 0.001). Conclusions RCC shades presented differential impacts on color change of CAD/CAM ceramics. Clinical significance Knowledge of the impact of available RCC shades on different CAD/CAM ceramics is crucial for an esthetic outcome and proper selection of ceramic restorations.