Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for uninfected children. HIV-infected adolescents not receiving antiretroviral treatment had worse health perceptions and symptoms. We found no consistent QoL differences among children receiving different antiretroviral regimens.

SummaryA child with homozygous partial deletion of the DOCK8 gene showed characteristic clinical findings of autosomal recessive hyper-IgE syndrome and full donor chimerism early after matched sibling bone marrow transplantation. KeywordsImmunodeficiency; Hyper-IgE; Bone Marrow Transplantation; Hypereosinophilia To the Editor:The Hyper IgE syndromes (HIES) are rare combined immune deficiencies associated with marked elevations in plasma IgE levels and eosinophilia. An autosomal dominant form of HIES due to mutations in STAT3 is characterized by elevated IgE, eosinophilia, eczema, recurrent skin and pulmonary infections, and skeletal abnormalities 1 . Recently, an autosomal recessive form of HIES due to mutations in the dedicator of cytokinesis (DOCK)-8 gene has been identified and is characterized by elevated IgE levels, eosinophilia, atopic dermatitis, asthma, food allergies, recurrent upper and lower respiratory tract infections, and unusual susceptibility to infections with herpesvirus family members (herpes simplex virus (HSV), human papilloma virus (HPV)) and molluscum contagiosum 2, 3. Cutaneous infections with

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