A sample of 85 seniors was given experience (10 trials) playing two computer tasks using four input devices (touch screen, enlarged mouse [EZ Ball], mouse, and touch pad). Performance measures assessed both accuracy and time to complete components of the game for these devices. As well, participants completed a survey where they evaluated each of the devices. Seniors also completed a series of measures assessing visual memory, visual perception, motor coordination, and motor dexterity. Overall, previous experience with computers had a significant impact on the type of device that yielded the highest accuracy and speed performance, with different devices yielding better performance for novices versus experienced computer users. Regression analyses indicated that the mouse was the most demanding device in terms of the cognitive and motor-demand measures. Discussion centers on the relative benefits and perceptions regarding these devices among senior populations.