3-Arylpiperidines as Potentiators of Existing Antibacterial Agents.-A potent agent (V) against Gram-negative bacteria is created and compared with other derivatives and the lead structure (VI). It shows good membrane permeability. Tether length significantly influences the desired activity; the best results can be achieved by two-carbon bridging. The fluoro substituent is less important in contrast to earlier reported studies. -(THORARENSEN, ATLI; PRESLEY-BODNAR, ALICE L.; MAROTTI, KEITH R.; BOYLE, TIMOTHY P.; HECKAMAN, CHARLOTTE L.; BOHANON, MICHAEL J.; TOMICH, PAUL K.; ZURENKO, GARY E.; SWEENEY, MICHAEL T.; YAGI, BETTY H.; Bioorg. Med.
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