As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are increasingly being released into the natural environment. Substantial concerns have been raised regarding the environmental and health impacts of M/NPs. Although diverse M/NPs have been detected in natural environment, most of them display two similar features, i.e.,high surface area and strong binding affinity, which enable extensive interactions between M/NPs and surrounding substances. This results in the formation of coronas, including eco-coronas and bio-coronas, on the plastic surface in different media. In real exposure scenarios, corona formation on M/NPs is inevitable and often displays variable and complex structures. The surface coronas have been found to impact the transportation, uptake, distribution, biotransformation and toxicity of particulates. Different from conventional toxins, packages on M/NPs rather than bare particles are more dangerous. We, therefore, recommend seriously consideration of the role of surface coronas in safety assessments. This review summarizes recent progress on the eco–coronas and bio-coronas of M/NPs, and further discusses the analytical methods to interpret corona structures, highlights the impacts of the corona on toxicity and provides future perspectives.
Лечение хронической обструктивной болезни лег ких (ХОБЛ) существенно затруднено. Ни один из преп аратов, применяемых для лечения этого заболе вания, в долговременной перспективе не позволяет предупредить прогрессирующее снижение функции легких. В настоящее время для терапии ХОБЛ широ ко применяются ингаляционные глюкокортикосте роиды (иГКС), поскольку они способны оказывать противовоспалительное действие [1]. Однако их эф фективность при ХОБЛ значительно ограничена [2]. Так, влияния иГКС на прогрессирование заболева ния и смертность не установлено, отмечается лишь
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