Sperm DNA damage, excessive oxidative stress and decrease in motility may lead to low fertilisation or poor assisted reproductive techniques outcomes in asthenoteratozoospermic men. Selenium was considered as essential element for male reproductive functions. Selenium has important role in enzymatic process for elimination of excessive reactive oxygen species and helps to maintain membrane integrity. The aim of this study was to determine the effect of selenium supplementation on sperm quality, DNA fragmentation, mitochondrial membrane potential and membrane lipid peroxidation during sperm sampling in vitro at different times. In this experimental study, semen samples were collected from 50 asthenoteratozoospermic men. Samples were divided into two groups as control group and test group (incubated with 2 μg/ml selenium at 37°C for 2, 4 and 6 hr). Motility and viability were assessed based on WHO 2010 criteria. Mitochondrial membrane potential, sperm DNA fragmentation and malondialdehyde levels were evaluated in each group. Results revealed that motility, viability and mitochondrial membrane potential were significantly higher in the test group (p < .05). Also malondialdehyde levels were significantly lower in the test group (p < .03). DNA fragmentation significantly decreased in the test group after 6 hr of incubation (p < .02). In conclusion, in vitro selenium supplementation may protect spermatozoa from maltreatment effect of reactive oxygen species (ROS) during sperm sampling via keeping enzymatic and antioxidant process in optimum condition.
results of present study suggest that prolonged use of methamphetamine exerts oxidative stress on the body and enhances lipid peroxidation. The event may contribute to emergence of adverse effects of acute and prolonged use of methamphetamine; such as loss of attention, psychomotor dysfunction, and cognitive deficits. It is recommended that antioxidants were included in drug regimens prescribed for methamphetamine abusers who referred to physicians to seek medical care for any reason.
Introduction:The purpose of this study is to measure Effectiveness of group dialectical behavior therapy (basedon core distress tolerance and emotion regulation components) on Expulsive Anger and Impulsive Behaviors.Materials & Methods:Research method is a semi experimental socio-statistic approach consisting of experimental group (dialectical behavior therapy) and control group. Participants were patients referred to Amir Kabir Hospital in Arak who suffered from Expulsive Anger and Impulsive Behaviors. Based on stratified random sampling, 16 patients (women) were placed in each group. Research tools included the structured diagnosis interview according to DSM-IV-TR (2000), Barrat impulsivity scale (1994) Distress Tolerance Scale (2005) Difficulties of Emotion Regulation Scale (2004) and dialectical behavior therapy were done for two months,8 group-sessions).Findings:Dialectical behavior therapy was effective on Expulsive Anger and Impulsive Behaviors.Discussion & Conclusion:Distress tolerance and emotion regulation components were effective on Expulsive Anger and Impulsive Behaviors.
Background and Objectives The use of antioxidant supplements improves and reduces oxidative stress factors following intense intense exercise. Exhaustion was performed in female athletes. Subjects and Methods 14 female athletes with an age range of 20 to 28 years and a maximum oxygen consumption of 42-52 m/kg/min in a quasi-experimental design randomly divided into two groups receiving coenzyme Q10 supplementation and placebo (5 mg/kg body weight). Were. After 14 days of coenzyme Q10 supplementation, the subjects performed an intense, debilitating activity. Urine samples were collected in three stages (baseline, before and 24 hours after exhaustive activity) to determine the concentration of 8-OHdG and MDA. Results There was a significant difference of 62% in the increasing response of urinaryOHdG-8 to an exhausting aerobic exercise session (P = 0.003). However, the 2% difference in the increasing urinary MDA response of the supplement and placebo groups was not significant after the last quasi-competitive aerobic training session (P = 0.7). Conclusion According to the results of the study, two weeks of high-pressure aerobic training causes DNA damage and lipid peroxidation in female athletes, and supplementation with Q10 helps prevent the 8-OHdG response of female athletes after a strenuous high-pressure aerobic training session and reduces DNA damage. Become athlete
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