The current Study was done to show the physiological and histological defect at different doses of diclofenac sodium on livers of Rabbits. Twenty rabbits was divided into four groups the therapiutic group (T) , over does group1 (T1), over dose group2 (T2) and control group each group was injected intraperitoneally by (2 , 20 , 50 mg/km) respectively and Distilled water, respectively for 14 days, at the fourteen day of experiment all animals were sacrificed, blood sample collected and liver was fixed immediately in 10% formalin for histological preparation and obtained serum for physiological test. There was no significant difference at the level of (0.05 <P) in the effectiveness of the Alanine aminotranseferase (ALT) and Aspartate aminotranseferase and gamma-glutamate transferase (GGT) in the serum of male rabbits in the T group and T1 group compared to the control group. Microscopic examination of the liver tissue in T group showed the presence of degeneration of hepatocytes and swelling of hepatocytes. showed edematous cells, infiltration of inflammatory cells in sinusoids in T1 group. In T2 group it showed colloid appearance in blood vessel, disappear of sinusoid, cell degeneration, degeneration of tunic cells of blood vessels.
Research has been designed to focusing and evaluation the effect of cypermethrin as insecticide material in the skin of the rabbits. Cypermethrin was applied on the skin after shaving the dorso-lateral aspect of rabbits .The animals (12) were classified into four groups (A, B, C and D), three animals per group. Groups (B, C and D) were exposed to cypermethrin at doses (0.001, 0.005, 0.010)mg/kg respectively, while (A) was a control group. After ten days of drug's application, animals of group (D) were died at ending of the study because they received heavy dose. The groups (B and C) shown excitation signs, followed by inhibition and depression of their activity. The animals of groups (A, B and C) were scarified and a specimens (0.5) cm3 of skin from the dorso- lateral aspect were obtained, washed with water and put in formalin (10)% then processed after (24) hours by using histological technique, sectioned at (5)µm thickness, stained with Hematoxylin and Eosin a then examined under light microscopic at different powers. http://dx.doi.org/10.25130/tjps.25.2020.022
The current Study was done to show the physiological and histological defect at different doses of diclofenac sodium on heart of Rabbits twenty rabbits was divided into four groups the therapeutic group (T) , over does group1(T1), over dose group2 (T2) and control group each group was injected intraperitoniali by ( T,T1 ,T2 ) mg/kg and Distiled water, respectively for 14 days, at the fourteen day of experimental animals were sacrificed, blood sample collected and heart was fixed immediately in 10% formalin for histological preparation and obtained serum for physiological test the result was revealed , T group significant decreases in lipoproteins so as to significant of low density-lipoproteins on ( p < 0.05 ) ( VLDL-C ). on the other hands the results showed significant differences on level of creatine kinase , troponin and lactate dehydrogenase , and in T2 group significant decreases of creatine kinase ,troponin and lactate dehydrogenase on ( P < 0.05 ) compared with control group. The histological examination of T groups was revealed degeneration in muscles fibers, zonal vacuolation around the nucleus of muscle fiber the result of T2 groups showed, atrophy in muscle fibers degeneration was appear of whole section spread out at inflammatory cells in between muscle fibers and zonal vacuolation around nucleus of muscle fibers. The results obtained from T2 groups was show atherosclerosis on marginal blood vessels of heart, hemolysis of RBCs with spread out of hemocidrin out of blood vessels.
The present study was done on skin of horse,samples are taken from six animals after anaesthetized the animals and slaughttered . Samples are taken from dorsal back area ,the collected tissues were fixed in 10% formalin for 24 hrs. tissue was prepared for light microscopic examination . the result showed skin of horse composed of Epidermis & dermis .epidermis are keratinized stratified squamous epithelium ,that divided into four cellular layers from the top (stratum corneum ,granulosum ,spinosum and basale), stratum basale are consist of simple cubiodal epithelium cells were rest on the basement membrane, Melanocytes cells are located in stratum basale .Dermis composed of papillary layer and dermal papilla. Papillary layer composed of bundles of collagenouse fibers with fibroblast. Primary hair follicles. primary hair follicle which surrounded by sweat glads and sebaceous glands. sweat glands was simple tubular gland which lined by simple cuboidal epithelium, the alveoli of sweat gland that surrounded by Myoepithelial cells. Sebeceous gland, Like double saccule, lined by simple cubiodal epithelium cells that contain fat dropletes. Primary hair follicle, that consist of Hair shaft in the center which represented the medulla, it was enclosed by cortical layer of stratified squamous epithelium.The primary & secondary hair follicle were attached to the smooth muscle bundles, was represented the arector pilli muscles. Small artery near the hair follicle that supply the oxygen and nutrient to the skin.
Research has been designed to focusing and evaluation the effect of cypermethrin as insecticide material in the skin of the rabbits. Cypermethrin was applied on the skin after shaving the dorso-lateral aspect of rabbits .The animals (12) were classified into four groups (A, B, C and D), three animals per group. Groups (B, C and D) were exposed to cypermethrin at doses (0.001, 0.005, 0.010)mg/kg respectively, while (A) was a control group. After ten days of drug's application, animals of group (D) were died at ending of the study because they received heavy dose. The groups (B and C) shown excitation signs, followed by inhibition and depression of their activity. The animals of groups (A, B and C) were scarified and a specimens (0.5) cm3 of skin from the dorso- lateral aspect were obtained, washed with water and put in formalin (10)% then processed after (24) hours by using histological technique, sectioned at (5)µm thickness, stained with Hematoxylin and Eosin a then examined under light microscopic at different powers.
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