Apart from cultural and scientific heritage, human beings can also inherit genetic disorders, such as trinucleotide repeat disorders. These disorders, with the genetic accumulation of repeat sequences, may cause disease in following generation and may lead to even more severe diseases in future generations. Although the formation mechanisms of many of these disorders are known, there are no findings on treatment aside from eliminating symptoms. This review will provide a general and up-to-date overview of some of the trinucleotide repeat diseases.The magnificent quintet of trinucleotid repeat disorders: Spinal and bulbar muscular atrophy, Huntington's disease, Friedreich ataxia, myotonic dystrophy, and fragile X syndrome ÖZ İnsanoğlu kültürel ve bilimsel miraslarının dışında trinükleotid tekrar hastalıklar gibi genetik sorunlarını da miras bırakabilmektedir. Bu bozukluk tekrar dizilerinin birikimiyle birlikte gelecek kuşaklarda hastalıklar oluşturabilmekte ve sonraki kuşaklarda daha ağır tablolara yol açabilmektedir. Birçoğunun oluşum mekanizması bilinse de tedavileri hakkında semptomları gidermek dışında bulunabilmiş bir sonuç mevcut değildir. Bu derlemeyle trinükleotit tekrar hastalıklarının bazılarına genel ve güncel bir bakış sağlanabilecektir.Anahtar sözcükler: Fragil X sendromu; Friedreich ataksisi; Huntington hastalığı; miyotonik distrofi; spinal bulbar musküler atrofi.
Objectives: This study investigates the relationship between anxiety and headphone use. Materials and methods: The study was conducted on 180 (54 males, 126 females) undergraduate students. Headphone habits were assessed with a questionnaire, and anxiety levels were assessed with Beck Anxiety Inventory. Results: While there was no correlation between total anxiety scores and length of headphone use, there was a correlation with purpose of headphone use. There was a positive correlation between headphone use while using a computer (p<0.05), watching media, isolation from the environment, and while studying (p<0.01), as well as a positive correlation with headphone use in evening hours (p<0.05). According to the Beck scale, participants with scores between 26-63 had high anxiety levels and were positively correlated with headphone use in the evenings, headphone use at school, and when watching media (p<0.05). Conclusion: Our study, which aimed to investigate the relationship between headphone habits and anxiety, may inspire and guide further studies on this subject.
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