This study presents experimental and numerical investigations on seven one-way, reinforced concrete (RC) slabs with a new technique of slab weight reduction using polystyrene-embedded arched blocks (PEABs). All slabs had the same dimensions, steel reinforcement, and concrete compressive strength. One of these slabs was a solid slab, which was taken as a control slab, while the other six slabs were cast with PEABs. The main variables were the ratio of the length of the PEABs to the length of the slab (lp/L) and the ratio of the height of the PEABs to the total slab depth (hP/H). The minimum decrease in the ultimate load capacity was about 6% with a minimum reduction in the slab weight of 15%. In contrast, the maximum decrease in the ultimate load capacity was about 24% with a maximum reduction in the slab weight of 40%. Moreover, the mode of failure changed from flexure to shear failure, especially for those slabs with an lP/L ratio equal to one. The geometric and material non-linearity was adopted in the proposed finite element (FE) model to simulate the slabs with PEABs using Abaqus software. Good agreement was obtained between the developed FE and experimental results.
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.
The introduction of concrete damage plasticity material models has significantly improved the accuracy with which the concrete structural elements can be predicted in terms of their structural response. Research into this method's accuracy in analyzing complex concrete forms has been limited. A damage model combined with a plasticity model, based on continuum damage mechanics, is recommended for effectively predicting and simulating concrete behaviour. The damage parameters, such as compressive and tensile damages, can be defined to simulate concrete behavior in a damaged-plasticity model accurately. This research aims to propose an analytical model for assessing concrete compressive damage based on stiffness deterioration. The proposed method can determine the damage variables at the start of the loading process, and this variable continues to increase as the load progresses until complete failure. The results obtained using this method were assessed through previous studies, whereas three case studies for concrete specimens and reinforced concrete structural elements (columns and gable beams) were considered. Additionally, finite element models were also developed and verified. The results revealed good agreement in each case. Furthermore, the results show that the proposed method outperforms other methods in terms of damage prediction, particularly when damage is calculated using the stress ratio. Doi: 10.28991/CEJ-2022-08-02-03 Full Text: PDF
Reinforced concrete slabs are one of the most important and complicated elements of a building. For supported edges slabs, if the ratio of long span to short span is equal or less than two then the slab is considered as two-way slab otherwise is consider as one-way slab. Two-way reinforced concrete slabs are common in use in reinforced concrete buildings due to geometrically arrangement of columns suggested by architects who prefer a symmetric distribution of columns in their plans. Elastic theory is usually used for analysis of concrete slabs. However, for several reasons design methods based on elastic principles are limited in their function. Correspondingly, limit state analysis offers a powerful technique for considering such matter. The Yield Lines Theory, which is one of limit state analysis based on expected failure criteria of slabs. The assumed failure criteria is termed by a pattern of yield lines, along that the reinforcement has yielded and the location of which counts loads and boundary conditions. This paper deals with comparison of Method 3 for two-way slabs that was provided by the ACI Code and exact derivation of this method by the Yield Lines Theory. Total of nine cases of slabs that have been described by method three are studied and evaluated by plastic analysis assumptions of the yield lines theory. The results are summarized in terms of proposed formulae that derived according to the Yield Lines Ttheory, which could be used as an alternative method for design of two-way reinforced concrete slabs in the ACI Code.
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