Background: Anorexia and cachexia are one of the major problems in patients suffering from advanced malignancies. Objectives: This study aimed at evaluating the efficacy of herbal combination containing Fenugreek, Fennel, and Chicory supplementation to the high-dose megestrol for the treatment of cancer-induced cachexia and anorexia. Methods: This quasi-experimental study was performed on 47 adult patients with advanced malignancy; they experienced anorexia and weight loss over the 2 past months and referred to a university-affiliated hospital (Omid) in Isfahan, Iran. Patients who had met the inclusion criteria were assigned to take either herbal combination or placebo tablets in addition to megestrol (160 mg daily) for a 2-month follow-up. All patients’ demographic information, weight changes, anthropometric indices, as well as the quality of life criteria were recorded at the baseline and after the duration of follow-up. Results: Patients in the herbal combination group experienced a mean weight gain of 1.5 kg, while patients in the placebo group had an average weight loss of 0.6 kg. Anthropometric indices including triceps skinfold thickness, mid-arm muscle circumference index, and grip strength were significantly improved in the herbal combination group. The other evaluated criteria such as quality of life, functional assessment of anorexia/cachexia therapy (FAACT), and some factors of Anderson criteria were significantly improved in the herbal combination group than the placebo group. Conclusions: Given the ameliorated results of the herbal combination supplementation in terms of weight gain and appetite improvement, as well as physical and quality of life enhancement, it seems that the herbal combination can be used as an adjunctive treatment for the management of patients suffering from cancer-induced cachexia and anorexia.
Introduction Patients suffering from solid tumors use a wide range of cytotoxic drugs. In this study, we aimed to detect, document, and descriptively analyze the potential drug–drug interactions in hospitalized solid tumor’s patients in a Middle Eastern referral oncology–hematology University-affiliated hospital. Materials and methods In this cross-sectional study, the medical record of solid tumor’s patients who were admitted to the referral oncological center in Isfahan, Iran, during the six months period (2018) were considered. We included all patients who had received at least two chemotherapy or nonchemotherapy drugs simultaneously. The potential drug–drug interactions between chemotherapy and nonchemotherapy drugs were evaluated with Lexi-Interact ver.1.1 online software. Results During the study period, a total of 141 cancer patients were recruited, and their drug therapy regiment was thoroughly analyzed. We detected 227 drug–drug interactions with moderate or major severity out of included patients in which 96, 71, 32, and 28 interactions were in the category of C, D, B, and X, respectively. One hundred and fourteen patients (80.8%) encountered at least one potential drug–drug interactions during their hospitalization. Mechanistically, most of drug–drug interactions (56.4%) were pharmacodynamics. Interaction between granisetron and metoclopramide were the top 10 detected interaction (11.4%). The interaction between docetaxel and carboplatin was the most frequent drug–drug interactions between oncology drugs (2.6% of total drug–drug interactions). Conclusion Potentially moderate or major drug–drug interactions frequently occur among solid tumor’s cancer patients necessitate the establishment of a clinical pharmacy service for providing relevant pharmacotherapy consultations to prevent this potentially serious concern.
Background: Sleep disorder is one of the most common problems in cancer patients involved in chemotherapy stages, which is caused by the side effects of anticancer drugs and the exacerbation of mental disorders. The aim of this study was to evaluate the effectiveness of sleep health education on sleep quality of cancer patients during chemotherapy stages. Materials and Methods: In this clinical trial, 70 cancer patients were selected in the chemotherapy phase and divided into two groups of 35. In the intervention group, two 60-min training sessions on sleep hygiene were educated, solutions of coping with the exacerbation of sleep disturbances were determined, and routine care was provided in the control group. Patients were evaluated for sleep disorders before and 1 and 3 weeks after the intervention by the Pittsburgh questionnaire and then the effect of this intervention compared between the two groups. Results: The mean score of sleep medication consumption in the intervention group was not significantly different between the three times ( P = 0.59), but the mean score of total sleep quality disorder and its other dimensions was significantly different between the three time points ( P < 0.05). Least significant difference post hoc test showed that the mean total score of sleep quality disorder and its dimensions except using sleep medication 1 week after the intervention was significantly less than before the intervention and 3 weeks after the intervention <1 week after the intervention in the intervention group ( P < 0.05). Conclusion: Sleep health education for cancer patients involved in chemotherapy can significantly have a positive effect on improving their sleep quality.
Introduction: Developing patients’ tolerance in receiving treatment and enhancing their life expectancy has been increasingly recognized as the important end-points in cancer disease. Objectives: This cross-sectional study aimed at exploring the relationship between received social support and its correlation with life expectancy in cancer patients during chemotherapy. Patients and Methods: Around 210 cancer patients were selected through simple sampling procedure from the clinics of Isfahan medical science University, Iran. Sherbourne and Stewart questionnaire and Miller questionnaire were used to assess social support and life expectancy, respectively. The collected data were analyzed by independent t test and linear regression. Results: We found a significant positive correlation between total social support score and life expectancy scores. Additionally, a significant positive correlation between different aspects of social support — tangible support, emotional support and kindness—with positive social interaction and life expectancy was detected. Conclusion: Our results highlights that social support may develop life expectancy in cancer patients depending on the extent of disease; however, extensive and longitudinal studies on social support and life expectancy in cancer patients should be performed.
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