The effect of some prepared oxadiazole compounds 5-[4-(p-methoxy phenyl) azo phenyl]-2thiol-1, 3, 4-Oxadiazole [ ], 5-[4-(methoxy phenyl) azo phenyl]-2-marcapto-alky-1, 3, 4-oxadiazole [-V](where alkyl group is ethyl, propyl, butyl and pentyl respectively) were tested on the activity of ALP, AST, and ALT in sera of 30 patients with hepatocellular cancer and 30 healthy individuals as control group. The results revealed significantly higher levels of ALP, AST, and ALT activity in patients group compared to control group. Different concentrations (10-4 , 10-5 , and 10-6 M) of oxadiazole derivatives showed different percentage of inhibitions, but did not showed proportional with the concentration of derivatives. The elevated values of ALP, AST, and ALT activity in sera of patients were returned to about normal values in most cases after addition of oxadiazole compounds to sera of patients in vitro.
A series of new phthalimides compounds [3][4][5][6][7] a-i were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo [d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo [d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1] a-i under fusion conditions. Compounds [3-7] a-i react with SOCl 2 in the presence of benzene to produce compounds [8-12] a-i . Chemical modification of Poly(vinyl alcohol)were obtained by reaction of PVA with compounds [8-12] a-i using the dimethyl formamide to give compounds [13-17] a-i . The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra, 1 H, 13 C-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.