Background: Pulmonary fibrosis is an idiopathic and chronic inflammatory interstitial lung disease that responds only weakly to available medical therapies and has a potentially fatal prognosis. Hibiscus sabdariffa L. contains several antioxidants, such as protocatechuic acid (PCA) and anthocyanins, which may be beneficial for the treatment of fibrosis.
Background: Pulmonary fibrosis is an idiopathic and chronic in[U+FB02]ammatory interstitial lung disease, with a negligible response to available medical therapies and potentially fatal prognosis. Statins (3-hydroxy-3-methylglutaryl-coenzyme A [HMG CoA] reductase inhibitors) have broad pleiotropic properties and are used to treat multiple diseases. Objectives: The purpose of this study was to investigate the effect of different doses of atorvastatin (10, 20, and 40 mg/kg) on bleomycin (BLM)-induced pulmonary fibrosis in rats.
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