From our research, there are some implications to treat the fatty liver patients for concerning of internal physician in the practice.Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common reasons of enzyme increase in liver. In About 10 percent of patients with NAFLD, the disease progresses toward Non Alcoholic Steatohepatitis (NASH) and about one third of them may progress toward cirrhosis, liver dysfunction, and even hepatocellular carcinoma. Objectives: According to high prevalence of NAFLD and the fact that there is no consensus on treatment of this disease, the aim of this study was to assess the effects of metformin, pioglitazone, and silymarin on treatment of NAFLD. Patients and Methods: Sixty six patients with NAFLD who were presented in the Endocrinology and Metabolism clinic of Boo'ali Hospital, Qazvin, Iran, were assigned randomly into three groups (n = 22). First group was treated by pioglitazone 15 mg/d, second group by metformin 500 mg/d, and third group by silymarin 140 mg/d. All patients underwent clinical and biochemical evaluations including weight, fasting blood sugar (FBS), lipid profiles, body mass index (BMI), aspartate aminotransferase (AST ), alanine aminotransferase (ALT), and serum insulin levels in pre-and post-intervention after eight-week follow up. Results: Before the treatment there was no significant difference between three groups with respect to average age, BMI and gender, FBS, lipid profile, AST, ALT, serum insulin level, and Homeostasis Model Assessment (HOMA) index for insulin resistance. After the intervention, a significant reduction was observed in average amount of FBS, lipid profile, ALT, AST, serum insulin level and HOMA index in three groups (P < 0.01). The most reduction in average FBS, TG, serum insulin level, and HOMA index was observed in pioglitazone group, the most reduction in average amount of cholesterol was seen in metformin group, and the most decrease in average amount of AST and ALT occurred in silymarin group. Conclusions: These results suggest that all drugs are beneficial in improving biochemical indices in patients with NAFLD. Changes in AST and ALT in silymarin group were demonstrated more than that in other groups and the average difference between changes was significant between silymarin and metformin groups.
Background & aims: Weight loss after proper diet is one of the main topics in nutrition. This study was designed to evaluate the effects of probiotic and alpha-Lipoic acid (ALA) supplements on the anthropometric indicators and maintenance of weight in overweight individuals. Methods: This study consisted of two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight participants were randomly divided into 4 groups in phase 1: isocaloric diet with probiotic (500 mg), an isocaloric diet with ALA (600 mg) and probiotic, an isocaloric diet with ALA and isocaloric diet with placebo. In phase 2, participants received a normal diet with the mentioned supplements. In the beginning, end of the phase 1, and at the end of phase 2, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, and blood pressure (BP) were measured. Also, 10 cc blood samples were taken from subjects to measure C-reactive protein (CRP). Data was analyzed using SPSS software. Results: At the end of the two phases, the differences of changes in the probiotic þ ALA group was significant in weight, WC, and CRP factors when compared to the other groups (P < 0.05). Also, at the end of the study, maintain a reduced weight was significantly higher in the probiotic þ ALA group than in the other groups (P < 0.05). Conclusion: According to findings, probiotics and ALA supplementation with normal diet help to maintain decreased weight after adhering to a weight loss diet. This may be due to the reduction of inflammation. Trial registration: (IRCT20141025019669N10).
Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Oxidative stress and inflammation play a major role in IBS. Considering the antioxidant properties of ellagic acid (EA), this study was designed to evaluate the effect of EA on oxidative stress index, inflammatory markers, and quality of life in patients with IBS. This research was conducted as a randomized, double-blind, placebo-controlled clinical trial; 44 patients with IBS were recruited. Patients who met the inclusion criteria were randomly allocated to consume a capsule containing 180 mg of EA per day (n = 22) or a placebo (n = 22) for 8 weeks. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), and interleukin-6 (IL-6) were measured at the beginning and the end of the study. Also, quality of life was assessed using a self-report questionnaire for IBS patients (IBS-QOL). At the end of the study, we saw a significant decrease and increase in the MDA and TAC in the intervention group, respectively (p < 0.05). Also, EA consumption reduced CRP and IL-6 levels, and these changes were significant in comparison with placebo group changes (p < 0.05). The overall score of IBS-QOL significantly decreased, and quality of life was increased (p < 0.05), but there were no significant changes in the placebo group. According to these findings, receiving polyphenols, such as EA, may help maintain intestinal health by modulating inflammation and oxidative stress and ultimately improving the quality of life in IBS patients. Trial Registration Iranian Registry of Clinical Trials Identifier: IRCT20141025019669N11
Background and Aim:The purpose of this study was to evaluate the effects of probiotic and alpha-lipoic acid (ALA) supplements, on appetite in overweight people. Materials and Methods:This study included two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight people were randomly divided into 4 groups: Isocaloric diet with probiotic (500mg), isocaloric diet with ALA (600mg) and probiotic, isocaloric diet with ALA and isocaloric diet with placebo groups. In the second phase, the participants received normal diet with the above -mentioned supplements. At the beginning and end of the first phase and at the end of the second phase, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, Creactive protein (CRP), and appetite were evalauted. We used SPSS software for statistical analysis. Independent sample t-test and ANOVA were used to compare the alterations in the mean values among the groups. Results: At the end of the first phase, the level of anthropometric changes, inflammatory factor and appetite were significant in the intervention groups, but these changes were higher in the probiotic + ALA group than in the other groups (P <0.05). At the end of the second phase we found significant changes only in the probiotic + ALA group (P<0.05). Conclusion: Addition of probiotic and ALA supplements to the normal diet can be effective in appetite and weight management and also maintainance of weight loss which may be due to decreased inflammation.
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