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IntroductionHeadache disorders are among the most common 10 causes of disability worldwide according to the global burden of disease survey 2010. Headache is also wildly common among universities students when compared with other populations. The purpose of this study is to assess headache prevalence among Aleppo University medical, dental and pharmaceutical undergraduate students.MethodsA questionnaire-based cross-sectional study was conducted among medical, dental and pharmaceutical students at Aleppo University, Syria. We determined the type of headache according to the International Classification of Headache Disorder-III. The total number of participants was 2068. A χ2 test was used to evaluate the association between the categorical outcomes. P<0.05 was considered significant.ResultsOut of 2068 participants, 1604 (77.6%) were medical students, 205 (9.9%) were dental students and 259 (12.5%) were pharmaceutical students. The effect on daily activities was higher in chronic tension headache (96.7%) and migraine without aura (94.6%) than migraine with aura (91.3) and episodic tension headache (85.1%). Out of 1191 who had a headache, only 188 (15.9%) had a medical consultation.ConclusionsThere was no a statistically significant difference in prevalence of tension headache and migraine according to faculties. There was a statistically significant difference in patients with migraine according to academic year, living with family and smoking. The effect on daily activities was higher in chronic tension-type headache and migraine without aura. There is a significant lack of medical consultation among students and most of them took over the counter analgesics depending on personal choice.

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No treatment currently can be used in order to slow or even stop the progression of Parkinson's disease. Nowadays, researchers are already using stem cells to grow dopamine-producing nerve cells in the lab so that they can study the disease, especially in those cases where there is a known genetic cause for the condition. The development of the advanced cellular therapies and using induced pluripotent stem cells is making it possible to combat the progression of the disease without the resulting motor complications. It has been shown that the transplantation of many cell sources leads to reduce Parkinson’s disease symptoms in animal models.

BackgroundThe aim of this study was to compare cyclic fatigue resistance (CFR) and separation patterns during rotating movement of five heat-treated nickel titanium files in both single and double-curved canals. MethodsCFR was compared between five groups of 24 files each: HyFlex® EDM, HyFlex™ CM, Vortex Blue®, Protaper Next®, and One Curve, by determining the time needed to fracture (TTF) and the number of cycles to failure (NCF) in a cyclic fatigue testing device with a single 5-mm radius of curvature (ROC) and 60° angle, and a double curvature; coronal curvature (5 mm ROC and 60° angle) and apical curvature (2 mm ROC and 70° angle). The separation pattern was evaluated, and file fragment separated length were measured. One-way ANOVA and Tukey’s post-hoc were used to compare statistical differences between the groups. Scanning Electron Microscope (SEM) was used to investigate the fracture sites. Results HyFlex™ CM files displayed significantly higher CFR, followed by HyFlex® EDM and Vortex Blue® in single curvature canals, and Protaper Next® (PTN) in the double curvature canals, as observed by TFF and NCF. PTN group had the highest tendency for files to extrude apically after separation in both curvatures. ConclusionHyFlex™ CM instruments have superior resistance to cyclic flexural fatigue within single canals with single and double curvatures, followed by HyFlex® EDM and Vortex Blue® instruments. Protaper Next® files followed by One Curve had the highest tendency to extrude apically after separationClinical relevanceHyFlex™ CM instruments showed the highest safety in preparing canals with single or double curvatures, considering CFR.