IMPORTANCEOlder patients and those with comorbidities who are infected with SARS-CoV-2 may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody for the treatment of high-risk patients to prevent COVID-19 progression.OBJECTIVE To evaluate the efficacy and adverse events of sotrovimab in preventing progression of mild to moderate COVID-19 to severe disease.DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial including 1057 nonhospitalized patients with symptomatic, mild to moderate COVID-19 and at least 1 risk factor for progression conducted at 57 sites in Brazil, Canada,
BackgroundRecent studies suggest that surface muscular functional electrical stimulation (FES) might suppress neurological upper limb tremor. We assessed its effects on upper limb physiological tremor, which is mainly driven by mechanical-reflex oscillations. We investigated the interaction between FES and augmented visual feedback, since (a) most daily activities are performed using visual cues, and (b) augmented visual feedback exacerbates upper limb tremor.Methods10 healthy subjects (23.4 ± 7.7 years) performed 2 postural tasks with combinations of FES (4 sites; frequency of stimulation: 30 Hz; pulse width: 300 microsec; range of current delivered 10–34 mAmp) and augmented visual feedback.ResultsSpectral analysis of tremor showed a decrease of power spectral density to 62.18% (p = 0.01), of the integral in the 8-12 Hz frequency band to 57.67% (p = 0.003), and of tremor root mean square (RMS) to 57.16% (p = 0.002) during FES, without any changes in tremor frequency. Augmented visual feedback blocked the beneficial effect of FES, as confirmed by power spectral analysis (p = 0.01). We found a statistically significant interaction between augmented visual feedback and electrical stimulation (p = 0.039).ConclusionsAugmented visual feedback antagonizes the effects of FES on physiological tremor. The absence of changes of peak frequency argues against an effect of FES on mechanical properties of the upper limb.
Caracterização do processo de rigor mortis dos músculos da paleta (Triceps brachii) e dos músculos duros (Extensor/ Flexor) de javali (Sus scrofa) e maciez da carne Characterization of rigor mortis process of picnic shoulders muscles (Triceps brachii) and of forefoot muscles (Extensor/ Flexor) of wild boar (Sus scrofa) and meat tenderness
Thirteen parkinsonians with a long duration of the disease and longterm dopa therapy, seven of them showing severe on-off oscillations and 6 an "endof-dose impairment", were treated with a controlled release (HBS) preparation of L DOPA/benserazide for more than 3 years.Thereafter, selegiline was added in a progressively increasing dosage up to a maximum of 10 mg/day during 4 months, with the aim of a) further improving the longterm results and b) reducing the doses of the new formula of LDOPA.A significant decrease of early morning parkinsonism and reduction of motor disability throughout the day were observed; "wearing-off" cases showed better results compared with those presenting "on-off" oscillations. A mean reduction of 20 ' 70 in the doses of levodopa was achieved. Likewise, a mild reduction of dyskinesias and a mild-moderate enhancement of dystonias were recorded. Only one patient did not tolerate selegiline and two others received lower doses due to side-effects.Selegiline was capable of enhancing the antiparkinsonian effect of the new formula of LDOPA, while allowing a reduction of the doses administered. It must also be emphasized that such improvement was achieved in complicated patients, most of whom showed some deterioration of response in the late stages of long-term sustained-release levodopa treatment.
The goal of this research was to explore Mexican American cultural elements through folklore as a way of addressing cultural competence. Content analysis of 21 stories, which were collected from Mexican American older adults, indicated that strong family ties, gender roles, and religiosity are central cultural elements in Mexican American culture. Critically evaluating cultural factors and employing constructive cultural elements can assist social work professionals in providing effective social services to this population via culturally competent practice.
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