We report on two boys with facial anomalies, small hands and feet, joint contractures, thick skin, unusual tiptoe gait and lysosome-like inclusions in the hepatocytes, compatible with a diagnosis of geleophysic dysplasia (GD). One of them also had fibrosis and fatty degeneration of the liver. In both, the facial appearance was different and neither had short stature nor progressive cardiac valvular disease. These clinical findings, consistent with a mild form of GD, support the notion that this disorder may have a broader spectrum than initially suspected.
Purpose
The biomechanical properties of the polyurethanes implant material derived
from castor oil plant (Ricinus communis) were evaluated in a noncritical
bone defect model in rat tibia.
Methods
After three weeks of the implant application, the tibias were tested by means
of the biomechanical three-point flexion test and resistance, rigidity,
energy at maximum load and maximum energy were evaluated. Nonparametric
statistical analysis was performed.
Results
It was found that the group that received the implant behaved the same as the
intact control group and also showed a significant increase in maximum load
compared to the spontaneous repair group.
Conclusions
Our results indicate that the tibias with the implant material in a
noncritical bone defect recover normal biomechanical parameters in less time
than spontaneously.
We report on a 4-year-old boy with craniometadiaphyseal dysplasia (CMDD), wormian bone type. Component manifestations include a large head with prominent forehead, skull changes showing multiple wormian bones, wide long tubular bones without the usual metaphyseal flare, wide and short tubular bones without the normal diaphyseal constriction, and wide ribs and clavicles. In addition to these findings, the propositus, his brother, his father, and a paternal aunt all have parietal protuberances, which seem not related to CMDD. Parental consanguineity supports the autosomal recessive transmission of the condition.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.