In this paper, a mathematical analysis of the global dynamics of a viral infection model in vivo is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both extracellular and intracellular levels of infection. At present, most mathematical modeling of viral kinetics after treatment only addresses the process of infection of a cell by the virus and the release of virions by the cell, while the processes taking place inside the cell are not included. We prove that the solutions of the new model with positive initial values are positive, exist globally in time and are bounded. The model has two virus-free steady states. They are distinguished by the fact that viral RNA is absent inside the cells in the first state and present inside the cells in the second. There are basic reproduction numbers associated to each of these steady states. If the basic reproduction number of the first steady state is less than one, then that state is asymptotically stable. If the basic reproduction number of the first steady state is greater than one and that of the second less than one, then the second steady state is asymptotically stable. If both basic reproduction numbers are greater than one, then we obtain various conclusions which depend on different restrictions on the parameters of the model. Under increasingly strong assumptions, we prove that there is at least one positive steady state (infected equilibrium), that there is a unique positive steady state and that the positive steady state is stable. We also give a condition under which every positive solution converges to a positive steady state. This is proved by methods of Li and Muldowney. Finally, we illustrate the theoretical results by numerical simulations.
Global existence to the coupled Einstein-Maxwell-Massive Scalar Field system which rules the dynamics of a kind of charged pure matter in the presence of a massive scalar field is proved, in Bianchi I-VIII spacetimes; asymptotic behaviour, geodesic completeness, energy conditions are investigated in the case of a cosmological constant bounded from below by a strictly negative constant depending only on the massive scalar field.
The aims of this work is to analyse of the global stability of the extended model of hepatitis C virus(HCV) infection with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We first give general information about hepatitis C. Secondly, We prove the existence of local, maximal and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Thirdly we show, by the construction of an appropriate Lyapunov function, that the uninfected equilibrium and the unique infected equilibrium of the model of HCV are globally asymptotically stable respectively when the threshold number R 0 < 1 − q d I +q and when R 0 > 1. Finally, some numerical simulations are carried out using Maple software confirm these theoretical results.
In this paper, we present the global analysis of a HCV model under therapy.We prove that the solutions with positive initial values are global, positive, bounded and not display periodic orbits. In addition, we show that the model is globally asymptotically stable, by using appropriate Lyapunov functions.
Global existence of solutions is proved and asymptotic behavior is investigated, in the case of a positive cosmological constant and positive initial velocity of the cosmological expansion factor.
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