Major progress has been made in cancer research; however, cancer remains one of the most important health-related burdens. Sericulture importance is no longer limited to the textile industry, but its by-products, such as silk fibroin or mulberry, exhibit great impact in the cancer research area. Fibroin, the pivotal compound that is found in silk, owns superior biocompatibility and biodegradability, representing one of the most important biomaterials. Numerous studies have reported its successful use as a drug delivery system, and it is currently used to develop three-dimensional tumor models that lead to a better understanding of cancer biology and play a great role in the development of novel antitumoral strategies. Moreover, sericin’s cytotoxic effect on various tumoral cell lines has been reported, but also, it has been used as a nanocarrier for target therapeutic agents. On the other hand, mulberry compounds include various bioactive elements that are well known for their antitumoral activities, such as polyphenols or anthocyanins. In this review, the latest progress of using sericultural by-products in cancer therapy is discussed by highlighting their notable impact in developing novel effective drug strategies.
Varroa destructor is a parasitic mite that represents a major global threat for the Western honeybee Apis mellifera. This parasite managed to switch from its natural host the Eastern honeybee, A. cerana, and within a few decades, it spread among A. mellifera populations around the world. Today beekeepers are using a variety of different acaricides to keep the parasite population under control. However, for many of these substances, the parasite evolved resistance asking for the development of novel compounds. Hence the treatment is less suited as a sustainable tool in honeybee health; consequently, other alternative options are needed, and breeding of Varroa resistant honeybees have been suggested as a more sustainable solution. Here we reviewed the successful efforts and the apicultural procedures needed to be implemented to achieve resistant honeybees. We also describe the underlying resistance mechanisms and discuss the benefits of breeding within regional populations, considering the biodiversity aspects of A. mellifera.
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