Background/Aim: Thymic lipofibroadenoma is a benign growth of unknown etiology extremely rarely described in the literature, morphologically resembling lipofibroadenoma of the breast. The diagnosis is usually a postoperative surprise and is made by the anatomopathologist. Surgical resection is curative. Case Report: The presented case is the first reported in a woman, to date. The patient was successfully submitted to surgery and complete resection of the giant intrathoracic tumor was performed. The histopathological and immunohistochemical studies came to demonstrated the presence of a thymic lipofibroadenoma while the postoperative outcomes were favorable. Conclusion: In cases presenting large intrathoracic tumors complete resection is able to provide a significant improvement of the general condition of the patient, as well as a chance for cure.Thymic tumors are a rare disease compared to other types of intrathoracic malignancies being reported with an incidence of 1.5 per million (1, 2). The most commonly encountered thymic tumors are represented by thymomas and thymic carcinomas; except these categories, another subgroup, generally known as "thymic tumors of rare histology" has been described. These tumors are usually found randomly by the anatomopathologist, after surgical resection. Information concerning most of them is available in the literature exclusively as case reports, same as the one presented herein.
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