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In recent years there has been an increased interest in political science in the concept of “transparency.” The literature has emphasized the effects that government transparency can have, especially on democratic consolidation. Yet there has been very little research focusing on the causes of transparency. This study discusses some of the possible factors affecting government transparency and offers several aggregate tests of their relevance. It emphasizes the mechanisms through which governments adopt institutions supporting transparency in order to signal to their societies and to external actors that the information they offer is indeed credible. It argues that such signals are more likely to be offered as the public receives increasing amounts of alternative information from international organizations. The discussion thus links processes taking place at the international level with those in the domestic realm.

As intergovernmental organizations (IOs) have grown in number and influence, there has been an increase in calls for their accountability, not just to governments but also toward the general public. One of the principal ways they can improve their accountability is by becoming more transparent, that is, offering more information to the public. Over the past decade, some IOs have adopted official policies and changed their practices concerning public access to information, while others have not. This study asks which IOs are likely to be transparent. To answer this question, it derives several hypotheses based on the existing international relations literature as well as the literature explaining government transparency in the domestic realm. The hypotheses focus on the roles of the principal actors affecting access-to-information from IOs: member states, IO bureaucracies and international nongovernmental organizations. This study tests these hypotheses across 72 IOs by using three newly developed measures of transparency. It finds that some of the main factors that explain IO transparency are analogous to those that have affected government transparency at the domestic level.

Immunosuppression is often identified in cancer patients. The aim of this study was to evaluate several immune parameters for patients with breast and lung cancer. Immunophenotyping analysis showed that the cancer patients investigated had significantly lower absolute numbers of peripheral blood lymphocytes than controls. The immunosuppression was more evident for the breast cancer subgroup. The most severe immune defect noticed was the marked impairment of IFN-gamma secretion. A shift toward the Th2 phenotype as revealed by assessment of intracellular level of IFN-gamma and IL-4 was also noticed. The secretion of proinflammatory cytokines IL-1beta and TNF-alpha in whole blood cultures was not impaired. Although the proportion of activated cells was slightly lower than in the control group, our results showed that both peripheral T lymphocytes and NK cells of cancer patients could be induced to express early activation marker CD69 after ex vivo mitogen stimulation. In conclusion, our study revealed several immune defects in cancer patients. This suggests that an appropriate immunotherapeutical approach might be used to restore compromised immune functions with beneficial effects on both antitumor and general immunity.