This paper analyzes the European Commission of the Danube (ECD) attempt to provide its sanitary vision, on a modern basis, in an unhealthy area. The need to impose a public health policy at the mouth of the Danube was given by Sulina's position as the gateway to Europe, subject to intense transit that brought with it mobility of the disease. Doctors Jellinek, Vignard, Petrescu Hagi Stoica, were some of the pillars that formed the basis of the formation of this health policy, which through their work and observations, made Sulina has known worldwide, not only in commercial importance but also in health. The epidemic waves, but also the doctors' findings, led to the construction of adequate medical facilities. Starting with 1878, after the involvement of the Romanian authorities, combining the social model with the medical one, a series of measures are adopted, which confers a new dimension of public health at the mouth of the Danube
Introduction: Calcitonin measurement is important for the diagnosis and monitoring of medullary thyroid carcinoma. Unfortunately, in clinical practice, different detection systems assays are used in the follow-up of the patients, which can be misleading. Objective: To identify the correction factor for calcitonin measurement on two different immunoanalysers: DiaSorin-LiaisonXL (immunochemiluminescence) and CobasE601 (electro-immunochemiluminescence). Methods: We selected 89 registered CT samples (28-from men; 61-from women), that were analysed on CobasE601 with reported values between 0.5 pg/ml and 2812 pg/ml (128.5±513.98). These CT samples were selected randomly to cover as wide a range of values as possible, and represented either basal CT (n=38) or selected from CT stimulation tests (n=51). Samples were evaluated subsequently on DiaSorin-LiaisonXL. All patients gave their informed consent. Results: Between the two assays a segmented linear correlation was noted. We identified the following general linear regression equation: 1.108x+19.337 (p<0.05). The bias increased at high calcitonin values. Therefore, for a better accuracy we analysed the regression equation segmentally. A statistic difference (p<0.05) was noted for CT values ranged between 350-2600 pg/ml (n=31) on DiaSorin-LiaisonXL, for which the linear regression equation for CobasE601 becomes 1.009x+169.796. Conclusions: Calcitonin correction factors are highly important in the dynamic follow up of a patient suffering from medullary thyroid carcinoma when different detection systems assays are used to determine calcitonin. We identified the correction factors for calcitonin determination between two different frequently used chemiluminescence immunoanalysers: DiaSorin-LiaisonXL and CobasE601. However, it is strongly advisable to use the same analyser in order to establish biochemical evolution of calcitonin.
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